Immune Cell Trafficking to the Liver.
Journal
Transplantation
ISSN: 1534-6080
Titre abrégé: Transplantation
Pays: United States
ID NLM: 0132144
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
1
3
2019
medline:
2
6
2020
entrez:
1
3
2019
Statut:
ppublish
Résumé
The human liver is an organ with a diverse array of immunologic functions. Its unique anatomic position that leads to it receiving all the mesenteric venous blood, combined with its unique micro anatomy, allows it to serve as a sentinel for the body's immune system. Hepatocytes, biliary epithelial cells, Kupffer cells, stellate cells, and liver sinusoidal endothelial cells express key molecules that recruit and activate innate and adaptive immunity. Additionally, a diverse array of lymphoid and myeloid immune cells resides within and traffics to the liver in specific circumstances. Derangement of these trafficking mechanisms underlies the pathophysiology of autoimmune liver diseases, nonalcoholic steatohepatitis, and liver transplantation. Here, we review these pathways and interactions along with potential targets that have been identified to be exploited for therapeutic purposes.
Identifiants
pubmed: 30817405
doi: 10.1097/TP.0000000000002690
pmc: PMC7044802
mid: NIHMS1552558
doi:
Substances chimiques
Cell Adhesion Molecules
0
Chemokines
0
Receptors, Immunologic
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1323-1337Subventions
Organisme : NIAID NIH HHS
ID : R56 AI122332
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007854
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
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