[Neo-oogenesis in the adult ovary: What do we know?]
« Néo-ovogenèse dans l’ovaire adulte : mythe ou réalité ? ».
Cellules souches
DDX4
Ovaires
Ovary
Stem cell
Journal
Gynecologie, obstetrique, fertilite & senologie
ISSN: 2468-7189
Titre abrégé: Gynecol Obstet Fertil Senol
Pays: France
ID NLM: 101693805
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
21
08
2018
accepted:
22
02
2019
pubmed:
1
3
2019
medline:
15
1
2020
entrez:
1
3
2019
Statut:
ppublish
Résumé
For more than a decade, the existence of ovarian stem cells that can contribute to neo-oogenesis in the adult ovary is reported by some teams, challenging the dogma according to which mammalian females are born with a fixed and non-renewed germinal cell pool. The presence of germinal stem cells with mitotic activity suggests the possibility of potential postnatal oogenesis. These cells have both germ-line and stem cell markers in culture. They have been isolated using different strategies and their ability to differentiate into oocytes has been demonstrated since after reintroduction in an ovarian somatic environment, these cells generate follicles capable of producing healthy offspring in rodents. However, many scientists remain skeptical and question the reliability of the methods used. Despite that there is no consensus on the origin of these ovarian stem cells, private companies are now proposing to use their stem cell potential to treat human infertility.
Identifiants
pubmed: 30818039
pii: S2468-7189(19)30077-7
doi: 10.1016/j.gofs.2019.02.011
pii:
doi:
Substances chimiques
DDX4 protein, human
EC 3.6.1.-
Ddx4 protein, mouse
EC 3.6.1.-
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
478-483Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.