Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail.
EMT
Snail
mesenchymal type of migration
proteases
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
27 02 2019
27 02 2019
Historique:
received:
10
01
2019
revised:
08
02
2019
accepted:
20
02
2019
entrez:
2
3
2019
pubmed:
2
3
2019
medline:
2
3
2019
Statut:
epublish
Résumé
During tumor development and ongoing metastasis the acquisition of mesenchymal cell traits by epithelial carcinoma cells is achieved through a programmed phenotypic shift called the epithelial-to-mesenchymal transition, EMT. EMT contributes to increased cancer cell motility and invasiveness mainly through invadosomes, the adhesion structures that accompany the mesenchymal migration. The invadosomes and their associated proteases restrict protease activity to areas of the cell in direct contact with the ECM, thus precisely controlling cell invasion. Our data prove that Snail-overexpressing HT-29 cells that imitate the phenotype of colon cancer cells in the early stage of the EMT showed an increase in the expression and pericellular activity of cathepsin B. It appears that the pericellular localization of cathepsin B, also observed in colon and rectum adenocarcinoma tissue samples, plays a key role in its function.
Identifiants
pubmed: 30818851
pii: cells8030203
doi: 10.3390/cells8030203
pmc: PMC6468499
pii:
doi:
Substances chimiques
Snail Family Transcription Factors
0
Cathepsin B
EC 3.4.22.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Cell Sci. 2010 May 1;123(Pt 9):1427-37
pubmed: 20356925
Eur J Cell Biol. 2012 Nov-Dec;91(11-12):847-60
pubmed: 22673002
Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1143-54
pubmed: 25713304
Biochem Biophys Res Commun. 2011 Jan 28;404(4):1039-43
pubmed: 21187062
Curr Biol. 2011 Sep 13;21(17):1460-9
pubmed: 21856159
J Exp Clin Cancer Res. 2016 Jan 15;35:12
pubmed: 26769084
PLoS One. 2016 Mar 01;11(3):e0150226
pubmed: 26930497
Histochem Cell Biol. 2018 Aug;150(2):133-147
pubmed: 29789993
J Biol Chem. 2012 Oct 19;287(43):36556-66
pubmed: 22898815
Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5353-65
pubmed: 18641286
World J Biol Chem. 2013 Nov 26;4(4):91-101
pubmed: 24340132
Clin Exp Metastasis. 2017 Jun;34(5):295-307
pubmed: 28730323
Transgenic Res. 2009 Feb;18(1):1-5
pubmed: 19002597
Lab Invest. 2015 Jan;95(1):65-77
pubmed: 25384123
Genes Dev. 2006 Mar 1;20(5):543-56
pubmed: 16481467
J Theor Biol. 1985 Jun 7;114(3):413-31
pubmed: 4021503
J Cell Sci. 2013 Oct 15;126(Pt 20):4647-58
pubmed: 23902685
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Cancer Res. 2017 Dec 15;77(24):7027-7037
pubmed: 29046337
Trends Cell Biol. 2003 Jul;13(7):376-85
pubmed: 12837608
Science. 1981 Jun 5;212(4499):1151-3
pubmed: 7233209
Physiology (Bethesda). 2006 Oct;21:352-61
pubmed: 16990456
Eur J Cell Biol. 2017 Jun;96(4):289-300
pubmed: 28487031
J Cell Commun Signal. 2017 Jun;11(2):167-179
pubmed: 28070797
Pharmacol Res. 2017 May;119:313-326
pubmed: 28258008
Cancer Res. 2008 Nov 15;68(22):9147-56
pubmed: 19010886
Eur J Cell Biol. 2011 Feb-Mar;90(2-3):115-27
pubmed: 20609496
FASEB J. 2007 Aug;21(10):2486-95
pubmed: 17435175
J Cell Sci. 2009 Dec 1;122(Pt 23):4311-8
pubmed: 19887587
Biol Chem. 2015 Aug;396(8):867-82
pubmed: 25872877
Nat Rev Cancer. 2006 Mar;6(3):227-39
pubmed: 16498445
J Physiol. 2007 Dec 1;585(Pt 2):351-60
pubmed: 17916606
Brain Res. 2015 Oct 14;1623:30-8
pubmed: 25916577
Bioorg Med Chem. 2006 Jun 15;14(12):4260-76
pubmed: 16483784
Matrix Biol. 2019 Jan;75-76:102-113
pubmed: 29158162
J Biol Chem. 1995 Mar 10;270(10):5331-8
pubmed: 7890645
Expert Opin Ther Targets. 2008 Aug;12(8):1021-33
pubmed: 18620523
N Engl J Med. 1986 Dec 25;315(26):1650-9
pubmed: 3537791
Science. 2008 Sep 26;321(5897):1785-7
pubmed: 18818347
Mol Cell Proteomics. 2005 Dec;4(12):1920-32
pubmed: 16127175
Sci Rep. 2017 Feb 13;7:42369
pubmed: 28205573
Cancer Sci. 2010 Apr;101(4):843-7
pubmed: 20148894
Eur J Cell Biol. 2014 Oct;93(10-12):478-85
pubmed: 25012928
Biochimie. 2015 Jan;108:101-7
pubmed: 25446656
Science. 2017 May 26;356(6340):
pubmed: 28495876
Circulation. 2005 May 31;111(21):2820-7
pubmed: 15911696
Trends Cell Biol. 2013 Jan;23(1):16-21
pubmed: 22999190
Life Sci. 2016 Jan 15;145:174-83
pubmed: 26746659
Expert Opin Ther Targets. 2013 Mar;17(3):281-91
pubmed: 23293836
Cell Reprogram. 2013 Apr;15(2):101-6
pubmed: 23550730
Nat Rev Mol Cell Biol. 2019 Feb;20(2):69-84
pubmed: 30459476
Semin Cancer Biol. 2019 Oct;58:1-10
pubmed: 30453041
Mol Med. 2000 May;6(5):450-60
pubmed: 10952024
J Cell Biol. 2003 Jan 20;160(2):267-77
pubmed: 12527751
Nat Cell Biol. 2009 Dec;11(12):1487-95
pubmed: 19935649
Cell Oncol (Dordr). 2018 Apr;41(2):123-140
pubmed: 29568985
Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):716-28
pubmed: 16469948
Nat Cell Biol. 2015 May;17(5):533-9
pubmed: 25925582
Science. 2017 Aug 18;357(6352):
pubmed: 28818916
PLoS One. 2013 Aug 05;8(8):e70595
pubmed: 23940598
Eur J Cell Biol. 2011 Feb-Mar;90(2-3):181-8
pubmed: 20850195
J Cell Mol Med. 2010 Jun;14(6B):1569-93
pubmed: 19656240
Cancer Cell. 2017 Nov 13;32(5):654-668.e5
pubmed: 29136508
Breast Cancer Res. 2011;13(6):R115
pubmed: 22093547
Cell. 2009 Nov 25;139(5):871-90
pubmed: 19945376
J Cell Biol. 2016 Apr 11;213(1):109-25
pubmed: 27069022
Asian Pac J Cancer Prev. 2015;16(6):2187-91
pubmed: 25824735
Pharmacol Res Perspect. 2015 Jun;3(3):e00149
pubmed: 26171228
Neoplasia. 2008 Apr;10(4):363-70
pubmed: 18392131
Matrix Suppl. 1992;1:224-30
pubmed: 1480031
J Cell Sci. 2016 May 1;129(9):1759-68
pubmed: 27029343
Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2445-2453
pubmed: 27450890
Cancer Res. 2017 Nov 15;77(22):6400-6414
pubmed: 28951461
FEBS J. 2018 Jan;285(1):8-27
pubmed: 28548369
FEBS Lett. 1996 Sep 9;393(1):101-4
pubmed: 8804434
Front Cell Dev Biol. 2018 May 08;6:48
pubmed: 29868579
J Cell Sci. 2009 Sep 1;122(Pt 17):3037-49
pubmed: 19692590
Int J Oncol. 2010 Sep;37(3):663-8
pubmed: 20664935
Mediators Inflamm. 2017;2017:2570154
pubmed: 28642633
J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):117-34
pubmed: 20490631
J Pharmacol Toxicol Methods. 2010 Mar-Apr;61(2):205-9
pubmed: 20176119
Mol Biol Cell. 2017 Nov 15;28(24):3500-3516
pubmed: 28954862
Methods Mol Biol. 2011;769:111-36
pubmed: 21748673
Eur J Cell Biol. 2016 Nov;95(11):483-492
pubmed: 27465307
Essays Biochem. 2007;43:165-78
pubmed: 17705800
Mol Oncol. 2017 Jul;11(7):792-804
pubmed: 28649800
Eur J Immunol. 2012 Dec;42(12):3429-41
pubmed: 23018451
Curr Opin Cell Biol. 2014 Oct;30:74-82
pubmed: 24999834