Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4
Animals
CD4-Positive T-Lymphocytes
/ metabolism
CD8-Positive T-Lymphocytes
/ metabolism
Cytokines
/ metabolism
DNA Methylation
/ physiology
Epigenesis, Genetic
/ physiology
Hydrogen Peroxide
/ metabolism
Lymphocyte Activation
/ physiology
Male
Mice
Mice, Inbred C57BL
Mitochondria
/ metabolism
Oxidation-Reduction
Oxidative Stress
/ physiology
Signal Transduction
/ physiology
Superoxide Dismutase
/ metabolism
Superoxides
/ metabolism
Adaptive immunity
Apoptosis
Cytokines
Hydroxymethylation
Immune
Manganese superoxide dismutase
Metabolism
Methylation
Oxidative stress
Proliferation
Redox
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
04
01
2019
revised:
05
02
2019
accepted:
11
02
2019
pubmed:
2
3
2019
medline:
24
4
2020
entrez:
2
3
2019
Statut:
ppublish
Résumé
While the role of mitochondrial metabolism in controlling T-lymphocyte activation and function is becoming more clear, the specifics of how mitochondrial redox signaling contributes to T-lymphocyte regulation remains elusive. Here, we examined the global effects of elevated mitochondrial superoxide (O
Identifiants
pubmed: 30819616
pii: S2213-2317(19)30022-9
doi: 10.1016/j.redox.2019.101141
pmc: PMC6859572
pii:
doi:
Substances chimiques
Cytokines
0
Superoxides
11062-77-4
Hydrogen Peroxide
BBX060AN9V
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101141Subventions
Organisme : NHLBI NIH HHS
ID : R00 HL123471
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
Références
Cell. 2011 Sep 2;146(5):772-84
pubmed: 21871655
Am J Physiol Heart Circ Physiol. 2013 Jul 1;305(1):H19-28
pubmed: 23624625
PLoS One. 2011 Jan 06;6(1):e16013
pubmed: 21253614
Free Radic Biol Med. 2011 Feb 1;50(3):448-58
pubmed: 21130157
Nature. 2016 Sep 1;537(7618):63-68
pubmed: 27533040
PLoS One. 2016 Oct 11;11(10):e0164609
pubmed: 27727316
J Biol Chem. 2016 Feb 19;291(8):4256-65
pubmed: 26703470
J Immunol. 1994 Dec 1;153(11):4880-9
pubmed: 7963551
Free Radic Biol Med. 2007 May 15;42(10):1465-9
pubmed: 17448892
Blood. 2013 Mar 14;121(11):2059-63
pubmed: 23315164
Cell Commun Signal. 2014 Aug 01;12:50
pubmed: 25081034
Curr Biol. 2014 May 19;24(10):R453-62
pubmed: 24845678
Antioxid Redox Signal. 2014 Jan 10;20(2):281-94
pubmed: 24053613
Hypertension. 2016 Jun;67(6):1218-27
pubmed: 27067720
Nat Immunol. 2004 Aug;5(8):818-27
pubmed: 15258578
J Immunol. 2005 May 15;174(10):6080-7
pubmed: 15879102
J Immunol. 2010 May 1;184(9):4827-41
pubmed: 20335530
Immunity. 2013 Feb 21;38(2):225-36
pubmed: 23415911
Anal Chem. 2005 Jan 15;77(2):504-10
pubmed: 15649046
Antioxidants (Basel). 2017 Oct 30;6(4):null
pubmed: 29084153
Hypertension. 2015 Apr;65(4):916-23
pubmed: 25691620
PLoS One. 2016 Apr 27;11(4):e0154416
pubmed: 27120458
Cell Res. 2018 Mar;28(3):265-280
pubmed: 29219147
Redox Biol. 2017 Apr;11:82-90
pubmed: 27889641
Blood. 2009 Apr 9;113(15):3542-5
pubmed: 19050306
Nat Immunol. 2016 Apr;17(4):364-8
pubmed: 27002844
Science. 2013 Oct 11;342(6155):1242454
pubmed: 24115444
J Biol Chem. 2002 May 31;277(22):19585-93
pubmed: 11916964
Cancer Cell. 2017 Jul 10;32(1):71-87.e7
pubmed: 28697344
J Immunol. 2007 Nov 15;179(10):6456-67
pubmed: 17982034
Free Radic Biol Med. 2013 Mar;56:17-27
pubmed: 23219873
Sci Signal. 2010 Mar 30;3(115):ra24
pubmed: 20354224
J Exp Med. 2002 Jan 7;195(1):59-70
pubmed: 11781366
Cell. 2013 Jun 6;153(6):1239-51
pubmed: 23746840
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14336-41
pubmed: 23940348
Cell Rep. 2014 Jun 12;7(5):1343-1352
pubmed: 24835990
PLoS One. 2014 Aug 04;9(8):e104104
pubmed: 25090630
J Immunol. 2010 Nov 1;185(9):5247-58
pubmed: 20881184
Antioxid Redox Signal. 2011 Jul 15;15(2):551-89
pubmed: 20919933
Antioxid Redox Signal. 2013 Apr 20;18(12):1497-534
pubmed: 22938635
J Exp Med. 2015 Aug 24;212(9):1345-60
pubmed: 26261266
Mol Cell Biol. 2007 May;27(10):3625-39
pubmed: 17339328
EMBO J. 1995 Aug 1;14(15):3731-40
pubmed: 7641692
Nat Genet. 1995 Dec;11(4):376-81
pubmed: 7493016