Occupational exposure to inorganic particles during pregnancy and birth outcomes: a nationwide cohort study in Sweden.
Adult
Age Factors
Female
Humans
Infant, Newborn
Infant, Small for Gestational Age
Iron
/ poisoning
Longitudinal Studies
Maternal Exposure
/ adverse effects
Occupational Exposure
/ adverse effects
Particulate Matter
/ poisoning
Pregnancy
Pregnancy Complications
Premature Birth
/ epidemiology
Prospective Studies
Registries
Sweden
Young Adult
air pollution and welding
epidemiology
female reproductive effects and adverse pregnancy outcomes
inorganic dusts
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
27 02 2019
27 02 2019
Historique:
entrez:
2
3
2019
pubmed:
2
3
2019
medline:
4
3
2020
Statut:
epublish
Résumé
The aim of this study was to investigate if occupational exposure to inorganic particles or welding fumes during pregnancy is associated with negative birth outcomes. A prospective national cohort study. All single births from 1994 to 2012 in Sweden. Information on birth weight, preterm birth, small for gestational age, smoking habits, nationality, age, occupation, absence from work and education was obtained from nationwide registers. Exposure to inorganic particles (mg/m This study included all single births by occupationally active mothers (995 843). Associations between occupational exposures and negative birth outcomes in the form of low birth weight, preterm birth and small for gestational age. Mothers who had high exposure to inorganic particles and had less than 50 days (median) of absence from work during pregnancy showed an increased risk of preterm birth (OR 1.18; 95% CI 1.07 to 1.30), low birth weight (OR 1.32; 95% CI 1.18 to 1.48) as well as small for gestational age (OR 1.20; 95% CI 1.04 to 1.39). The increased risks were driven by exposure to iron particles. No increased risks were found in association with exposure to stone and concrete particles. High exposure to welding fumes was associated with an increased risk of low birth weight (OR 1.22; 95% CI 1.02 to 1.45) and preterm birth (OR 1.24; 95% CI 1.07 to 1.42). The results indicate that pregnant women should not be exposed to high levels of iron particles or welding fumes.
Identifiants
pubmed: 30819703
pii: bmjopen-2018-023879
doi: 10.1136/bmjopen-2018-023879
pmc: PMC6398675
doi:
Substances chimiques
Particulate Matter
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e023879Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Best Pract Res Clin Obstet Gynaecol. 2017 Jan;38:48-58
pubmed: 27940123
Part Fibre Toxicol. 2010 Sep 03;7:23
pubmed: 20815895
Pediatrics. 2012 Feb;129(2):338-48
pubmed: 22291121
Environ Health Perspect. 2006 Nov;114(11):1636-42
pubmed: 17107846
Occup Environ Med. 2008 Oct;65(10):655-8
pubmed: 18178587
Ther Adv Respir Dis. 2012 Apr;6(2):115-20
pubmed: 22323441
Occup Environ Med. 2012 Sep;69(9):651-7
pubmed: 22693266
Environ Health Perspect. 2016 Jun;124(6):855-60
pubmed: 26649754
Environ Toxicol. 2003 Aug;18(4):227-35
pubmed: 12900941
Eur Respir J. 2006 Aug;28(2):286-90
pubmed: 16641121
World J Gastroenterol. 2014 Jul 7;20(25):8082-91
pubmed: 25009380
J Air Waste Manag Assoc. 2018 Jan;68(1):12-28
pubmed: 28679072
Appl Occup Environ Hyg. 2001 Jan;16(1):84-91
pubmed: 11202032
Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):454-60
pubmed: 15006923
Int Arch Occup Environ Health. 2009 Mar;82(4):529-37
pubmed: 18820944
Int J Environ Res Public Health. 2016 Jun 14;13(6):
pubmed: 27314370
Matern Child Health J. 2012 Nov;16(8):1612-24
pubmed: 21769587
Fertil Steril. 2008 Feb;89(2 Suppl):e111-6; discussion e117
pubmed: 18308050
Occup Environ Med. 2014 Aug;71(8):529-35
pubmed: 24893704
Environ Int. 2011 Feb;37(2):498-516
pubmed: 21112090
Arch Pediatr Adolesc Med. 1994 Apr;148(4):377-83
pubmed: 8148937
Sci Rep. 2016 Sep 19;6:33515
pubmed: 27641436
Part Fibre Toxicol. 2016 Jun 10;13(1):31
pubmed: 27286820
Environ Health Perspect. 2006 Jun;114(6):905-10
pubmed: 16759993
J Air Waste Manag Assoc. 1995 May;45(5):320-82
pubmed: 7773805
Hypertension. 2012 Feb;59(2):226-34
pubmed: 22158643
Acta Paediatr. 1996 Jul;85(7):843-8
pubmed: 8819552
Lancet. 2008 Jan 5;371(9606):75-84
pubmed: 18177778
Occup Environ Med. 2013 Apr;70(4):213-22
pubmed: 23343859
Mutat Res. 2007 Apr 1;617(1-2):23-32
pubmed: 17328930
Toxicol Appl Pharmacol. 2003 Jul 15;190(2):157-69
pubmed: 12878045
Inhal Toxicol. 2006 Sep;18(10):741-7
pubmed: 16774863
Birth Defects Res C Embryo Today. 2016 Sep;108(3):196-206
pubmed: 27581067