Volumetric modulated arc therapy with robust optimization for larynx cancer.
Carotid artery
Dose uncertainty
Larynx
Robust optimization
VMAT
Journal
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
ISSN: 1724-191X
Titre abrégé: Phys Med
Pays: Italy
ID NLM: 9302888
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
10
08
2018
revised:
15
01
2019
accepted:
16
01
2019
entrez:
3
3
2019
pubmed:
3
3
2019
medline:
26
3
2019
Statut:
ppublish
Résumé
The aim of this study was to perform a comparison between robust optimization and planning target volume (PTV)-based optimization plans using volumetric modulated arc-therapy (VMAT) by evaluating perturbed doses induced by localization offsets for setup uncertainties in larynx cancer radiation therapy. Ten patients with early-stage (T1-2N0) glottis carcinoma were selected. The clinical target volume (CTV), carotid arteries, and spinal cord were contoured by a radiation oncologist. PTV-based and robust optimization plans were normalized at D The robust optimization plans exhibited superior CTV coverage and a reduced dose to the carotid arteries compared to the PTV-based optimization plans (p < 0.05). HI, CI The robust optimization plan may be a suitable treatment method in radiotherapy for larynx cancer patient.
Identifiants
pubmed: 30824150
pii: S1120-1797(19)30012-2
doi: 10.1016/j.ejmp.2019.01.012
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
54-58Informations de copyright
Copyright © 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.