Mixed chimerism established by hematopoietic stem cell transplantation is maintained by host and donor T regulatory cells.
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
12 03 2019
12 03 2019
Historique:
received:
30
08
2018
accepted:
21
01
2019
entrez:
3
3
2019
pubmed:
3
3
2019
medline:
15
4
2020
Statut:
ppublish
Résumé
Transplantation is an effective treatment of many clinical disorders, but the mechanisms that regulate immunological tolerance are uncertain and remain central to improving patient outcome. Hemopoietic stem cell transplantation (SCT) often establishes "mixed chimerism" in which immune cells from both the donor and patient coexist in vivo in a setting of immunological tolerance. We studied immune function in 69 patients within 2 months following SCT; 37 were fully donor and 32 displayed mixed chimerism. The proportion of T regulatory (Treg) cells was increased during mixed chimerism and comprised equal numbers of donor and host-derived regulatory cells. This was associated with a tolerogenic PD-L1
Identifiants
pubmed: 30824417
pii: bloodadvances.2018025502
doi: 10.1182/bloodadvances.2018025502
pmc: PMC6418492
doi:
Substances chimiques
B7-H1 Antigen
0
CD274 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
734-743Subventions
Organisme : Medical Research Council
ID : G110379
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K021192/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : RRAK17205
Pays : United Kingdom
Informations de copyright
© 2019 by The American Society of Hematology.
Références
Curr Opin Immunol. 2011 Oct;23(5):679-84
pubmed: 21802270
Nat Med. 2003 Sep;9(9):1144-50
pubmed: 12925844
Am J Transplant. 2012 May;12(5):1133-45
pubmed: 22405058
Nature. 1953 Oct 3;172(4379):603-6
pubmed: 13099277
Eur J Immunol. 2015 Sep;45(9):2470-9
pubmed: 26200095
Bone Marrow Transplant. 2015 Jun;50 Suppl 2:S82-6
pubmed: 26039215
Biol Blood Marrow Transplant. 2000;6(3A):309-20
pubmed: 10905768
Nat Med. 2004 Sep;10(9):987-92
pubmed: 15286785
Biol Blood Marrow Transplant. 2014 Nov;20(11):1758-66
pubmed: 25016197
Haematologica. 2010 Jun;95(6):989-95
pubmed: 19951968
Am J Transplant. 2004 Sep;4(9):1391-8
pubmed: 15307826
Sci Transl Med. 2015 Jan 28;7(272):272ra10
pubmed: 25632034
Blood. 2010 Nov 25;116(22):4501-11
pubmed: 20682852
Transplantation. 2002 Jun 15;73(11):1757-64
pubmed: 12084998
Science. 1945 Oct 19;102(2651):400-1
pubmed: 17755278
Biol Blood Marrow Transplant. 2013 Nov;19(11):1625-31
pubmed: 24035782
Biol Blood Marrow Transplant. 2014 Oct;20(10):1516-21
pubmed: 24907627
Biol Blood Marrow Transplant. 2004 May;10(5):337-46
pubmed: 15111933
Am J Transplant. 2006 Sep;6(9):2121-33
pubmed: 16796719
Blood. 2010 Oct 21;116(16):3080-8
pubmed: 20587785
Front Immunol. 2014 Feb 21;5:66
pubmed: 24600454
Leuk Res. 2013 May;37(5):561-5
pubmed: 23395505
J Clin Invest. 2010 Jul;120(7):2370-8
pubmed: 20530875
Biol Blood Marrow Transplant. 2003 May;9(5):320-9
pubmed: 12766882
Nat Rev Nephrol. 2010 Oct;6(10):594-605
pubmed: 20808286
Theor Med Bioeth. 1998 Sep;19(5):441-55
pubmed: 10023193
Transplantation. 1999 Aug 27;68(4):480-4
pubmed: 10480403
Am J Transplant. 2008 Apr;8(4):793-802
pubmed: 18261176
N Engl J Med. 2008 Jan 24;358(4):362-8
pubmed: 18216356
Blood. 1993 Oct 1;82(7):2216-23
pubmed: 7691252
Biol Blood Marrow Transplant. 2007 May;13(5):550-9
pubmed: 17448914
J Immunol. 2005 Jul 15;175(2):665-76
pubmed: 16002661
J Exp Med. 1985 Jun 1;161(6):1483-502
pubmed: 3159819
Immunology. 2014 Jan;141(1):123-31
pubmed: 24116901
Blood. 2008 Dec 1;112(12):4371-83
pubmed: 19029455
Blood. 2004 Apr 1;103(7):2677-82
pubmed: 14630824
J Exp Med. 2002 Aug 5;196(3):389-99
pubmed: 12163567
Biol Blood Marrow Transplant. 2015 Nov;21(11):1948-54
pubmed: 26183077
Blood. 1990 Dec 15;76(12):2462-5
pubmed: 2265242
Br J Haematol. 2007 Aug;138(4):517-26
pubmed: 17608767
Blood. 1978 Jun;51(6):1087-105
pubmed: 25684
Biol Blood Marrow Transplant. 2014 Aug;20(8):1139-44
pubmed: 24727332
Leuk Lymphoma. 2009 Nov;50(11):1809-17
pubmed: 19821799
J Immunol. 2013 Dec 15;191(12):5867-74
pubmed: 24198283
Nat Med. 2005 Nov;11(11):1244-9
pubmed: 16227991
Blood. 2004 Jun 1;103(11):4216-21
pubmed: 14976053
Cold Spring Harb Perspect Med. 2014 Jan 01;4(1):a015529
pubmed: 24384815
J Immunol. 2018 Jan 15;200(2):834-846
pubmed: 29212909
Transplantation. 1995 Jan 27;59(2):256-62
pubmed: 7839449