Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity.

Autoantibodies / immunology Autoantigens / immunology Autoimmune Diseases / immunology B-Lymphocytes / immunology Female HEK293 Cells Humans Male Middle Aged Nerve Tissue Proteins / immunology

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 04 2019
Historique:
received: 24 09 2018
accepted: 01 02 2019
pubmed: 3 3 2019
medline: 28 12 2019
entrez: 3 3 2019
Statut: ppublish

Résumé

The aim of this study was to test whether autoantibodies against neurologic surface Ags are found in nonneurologic autoimmune diseases, indicating a broader loss of tolerance. Patient and matched healthy donor (HD) sera were derived from four large cohorts: 1) rheumatoid arthritis (RA) (

Identifiants

DOI: 10.4049/jimmunol.1801295 PMID: 30824481 PMC: PMC6452031
pubmed: 30824481
pii: jimmunol.1801295
doi: 10.4049/jimmunol.1801295
pmc: PMC6452031
mid: NIHMS1521110
doi:

Substances chimiques

Autoantibodies 0
Autoantigens 0
Nerve Tissue Proteins 0

Types de publication

Clinical Trial Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2210-2219

Subventions

Organisme : NIGMS NIH HHS
ID : U54 GM104938
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI070352
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : P30 AR073750
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI101990
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI046130
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR053483
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI114780
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI101981
Pays : United States
Organisme : Wellcome Trust
ID : 104079/Z/14/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U01 AI101934
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI039671
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI045757
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI114780
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI073748
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2019 The Authors.

Références

Clin Immunol. 2011 Mar;138(3):247-54
pubmed: 21169067
Neurol Neuroimmunol Neuroinflamm. 2015 Jul 02;2(4):e131
pubmed: 26185777
Ann Neurol. 2009 Nov;66(5):617-29
pubmed: 19938104
Arthritis Rheum. 1999 Apr;42(4):599-608
pubmed: 10211873
JCI Insight. 2017 Sep 7;2(17):
pubmed: 28878127
Arthritis Rheum. 1997 Sep;40(9):1725
pubmed: 9324032
Arch Neurol. 2008 Jan;65(1):78-83
pubmed: 18195142
Neurology. 2016 Aug 30;87(9 Suppl 2):S67-73
pubmed: 27572864
Neurology. 2012 May 15;78(20):1601-7
pubmed: 22551731
Nat Med. 2001 Mar;7(3):365-8
pubmed: 11231638
Curr Dir Autoimmun. 2001;4:252-82
pubmed: 11569406
JAMA Neurol. 2018 Apr 1;75(4):478-487
pubmed: 29305608
J Neurol Neurosurg Psychiatry. 2017 Feb;88(2):132-136
pubmed: 27951522
Exp Neurol. 2015 Aug;270:66-71
pubmed: 25783660
Arthritis Rheumatol. 2018 Feb;70(2):277-286
pubmed: 29073350
Nat Med. 2007 Feb;13(2):211-7
pubmed: 17237795
Neurology. 2011 Aug 9;77(6):580-8
pubmed: 21795651
Brain. 2008 Nov;131(Pt 11):3072-80
pubmed: 18945724
Curr Rheumatol Rep. 2014 May;16(5):419
pubmed: 24643396
J Neuroinflammation. 2016 Nov 1;13(1):281
pubmed: 27802825
Brain. 2008 Jul;131(Pt 7):1940-52
pubmed: 18515870
Neurology. 2015 Jul 14;85(2):177-89
pubmed: 26092914
Arthritis Rheum. 2009 Dec 15;61(12):1735-42
pubmed: 19950324
Neurol Neuroimmunol Neuroinflamm. 2015 Mar 19;2(3):e89
pubmed: 25821844
J Clin Invest. 2013 Jun;123(6):2737-41
pubmed: 23676463
Ann Neurol. 2011 Feb;69(2):292-302
pubmed: 21387374
J Neurol. 2019 Apr;266(4):806-815
pubmed: 30607536
Ann Clin Transl Neurol. 2016 Apr 27;3(6):443-54
pubmed: 27547772
J Neuroimmunol. 2015 Dec 15;289:8-11
pubmed: 26616866
J Neurol Neurosurg Psychiatry. 2016 Sep;87(9):1005-15
pubmed: 27113605
Rheumatology (Oxford). 2019 May 1;58(5):908-913
pubmed: 30265368
Arthritis Rheumatol. 2017 Nov;69(11):2203-2208
pubmed: 28704602
J Neuroinflammation. 2017 Oct 25;14(1):208
pubmed: 29070051
Neurology. 2009 Jun 2;72(22):1960-1
pubmed: 19487655
Brain. 2007 May;130(Pt 5):1206-23
pubmed: 17439988
JAMA Neurol. 2014 Mar;71(3):276-83
pubmed: 24425068
Arthritis Rheum. 2010 Apr;62(4):1198-200
pubmed: 20131265
Neurology. 2017 Aug 29;89(9):900-908
pubmed: 28768844
Ann Intern Med. 2007 Jun 5;146(11):797-808
pubmed: 17548411
Mult Scler. 2018 Mar;24(3):331-339
pubmed: 28326889
Arthritis Rheum. 1988 Mar;31(3):315-24
pubmed: 3358796
Brain Pathol. 2013 Nov;23(6):661-83
pubmed: 24118483
J Neurol Neurosurg Psychiatry. 2017 Oct;88(10):811-817
pubmed: 28684532
J Neurol Sci. 2009 Sep 15;284(1-2):33-5
pubmed: 19394052
J Neuroinflammation. 2011 Dec 28;8:184
pubmed: 22204662
J Neuroinflammation. 2016 Sep 26;13(1):279
pubmed: 27788675
N Engl J Med. 2003 Oct 16;349(16):1526-33
pubmed: 14561795
Diabetes Care. 2010 Jan;33 Suppl 1:S62-9
pubmed: 20042775
Nature. 2015 Feb 19;518(7539):337-43
pubmed: 25363779
Scand J Rheumatol. 2011 Nov;40(6):486-90
pubmed: 21722072
Neurol Neuroimmunol Neuroinflamm. 2014 May 22;1(1):e11
pubmed: 25340055
Neurology. 2007 Dec 11;69(24):2221-31
pubmed: 17928579
J Exp Med. 2005 Aug 15;202(4):473-7
pubmed: 16087714
Sci Transl Med. 2017 Jul 5;9(397):
pubmed: 28679661
Rheumatology (Oxford). 2011 Jan;50(1):47-59
pubmed: 20864496
Mult Scler Relat Disord. 2019 Feb;28:125-128
pubmed: 30593981
N Engl J Med. 1975 Oct 9;293(15):760-1
pubmed: 1160955
Neurol Neuroimmunol Neuroinflamm. 2014 Oct 29;1(4):e40
pubmed: 25364774
Neurology. 2009 Mar 24;72(12):1101-3
pubmed: 19307546
PLoS One. 2013 Nov 07;8(11):e80695
pubmed: 24244707
N Engl J Med. 2018 Mar 1;378(9):840-851
pubmed: 29490181
Postgrad Med J. 1994 Oct;70(828):741-5
pubmed: 7831174
Arthritis Rheum. 2012 Nov;64(11):3677-86
pubmed: 23112091
J Neuroinflammation. 2016 Sep 27;13(1):280
pubmed: 27793206

Auteurs

Panos Stathopoulos (P)

Department of Neurology, Yale School of Medicine, New Haven, CT 06511.
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.

Anne Chastre (A)

Department of Neurology, Yale School of Medicine, New Haven, CT 06511.
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.

Patrick Waters (P)

Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 2JD, United Kingdom.

Sarosh Irani (S)

Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 2JD, United Kingdom.

Miriam L Fichtner (ML)

Department of Neurology, Yale School of Medicine, New Haven, CT 06511.
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
ORCID: 0000-0002-0107-4103

Erik S Benotti (ES)

Department of Neurology, Yale School of Medicine, New Haven, CT 06511.
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
ORCID: 0000-0002-2037-9420

Joel M Guthridge (JM)

Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Oklahoma Clinical and Translational Science Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.
ORCID: 0000-0002-9308-237X

Jennifer Seifert (J)

Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045; and.

Richard J Nowak (RJ)

Department of Neurology, Yale School of Medicine, New Haven, CT 06511.

Jane H Buckner (JH)

Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA 98101.
ORCID: 0000-0002-9005-1885

V Michael Holers (VM)

Department of Medicine, University of Colorado School of Medicine, Aurora, CO 80045; and.

Judith A James (JA)

Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Oklahoma Clinical and Translational Science Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.
ORCID: 0000-0002-9574-7355

David A Hafler (DA)

Department of Neurology, Yale School of Medicine, New Haven, CT 06511; kevin.oconnor@yale.edu david.hafler@yale.edu.
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.

Kevin C O'Connor (KC)

Department of Neurology, Yale School of Medicine, New Haven, CT 06511; kevin.oconnor@yale.edu david.hafler@yale.edu.
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06511.
ORCID: 0000-0002-7056-419X

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Autoantibodies against Neurologic Antigens in...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Autoantibodies against Neurologic Antigens in...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Autoantibodies against Neurologic Antigens in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Autoantibodies against Neurologic Antigens in...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Autoantibodies against Neurologic Antigens in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Autoantibodies against Neurologic Antigens in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Autoantibodies against Neurologic Antigens in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Autoantibodies against Neurologic Antigens in...