TBA
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
02
08
2018
accepted:
04
12
2018
entrez:
3
3
2019
pubmed:
3
3
2019
medline:
18
9
2020
Statut:
epublish
Résumé
Superantigens (SAgs) play a major role in the pathogenesis of Staphylococcus aureus and are associated with several diseases, including food poisoning, bacterial arthritis, and toxic shock syndrome. Monoclonal antibodies to these SAgs, primarily TSST-1, SEB and SEA have been shown to provide protection in animal studies and to reduce clinical severity in bacteremic patients. Here we quantify the pre-existing antibodies against SAgs in many human plasma and IVIG samples and demonstrate that in a major portion of the population these antibody titers are suboptimal and IVIG therapy only incrementally elevates the anti-SAg titers. Our in vitro neutralization studies show that a combination of antibodies against SEA, SEB,and TSST-1 can provide broad neutralization of staphylococcal SAgs. We report a single fusion protein (TBA
Identifiants
pubmed: 30824769
doi: 10.1038/s41598-019-39890-z
pii: 10.1038/s41598-019-39890-z
pmc: PMC6397225
doi:
Substances chimiques
Enterotoxins
0
Recombinant Fusion Proteins
0
Staphylococcal Toxoid
0
Superantigens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3279Subventions
Organisme : NIAID NIH HHS
ID : R01 AI111205
Pays : United States
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