Regulation of ERAP1 and ERAP2 genes and their disfunction in human cancer.
Aminopeptidases
/ genetics
Animals
Antigen Presentation
/ immunology
Endoplasmic Reticulum
/ metabolism
Gene Expression Regulation, Neoplastic
Genetic Variation
Genomics
/ methods
Histocompatibility Antigens Class I
/ immunology
Humans
Immunotherapy
Minor Histocompatibility Antigens
/ genetics
Neoplasms
/ genetics
Protein Binding
Transcription, Genetic
Aminopeptidase
Antigen processing
Cancer
Genetic alterations
Transcription factors
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
16
11
2018
revised:
01
02
2019
accepted:
26
02
2019
pubmed:
3
3
2019
medline:
16
11
2019
entrez:
3
3
2019
Statut:
ppublish
Résumé
The endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 are two multifunctional enzymes playing an important role in the biological processes requiring trimming of substrates, including the generation of major histocompatibility complex (MHC) class I binding peptides. In the absence of ERAP enzymes, the cells exhibit a different pool of peptides on their surface which can promote both NK and CD8
Identifiants
pubmed: 30825518
pii: S0198-8859(18)31061-9
doi: 10.1016/j.humimm.2019.02.014
pii:
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Minor Histocompatibility Antigens
0
Aminopeptidases
EC 3.4.11.-
ERAP1 protein, human
EC 3.4.11.-
ERAP2 protein, human
EC 3.4.11.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
318-324Informations de copyright
Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.