New sesquiterpenoids from the stems of Datura metel L.

China Datura metel / chemistry HeLa Cells Hep G2 Cells Humans Molecular Structure Phytochemicals / isolation & purification Plant Stems / chemistry Sesquiterpenes / isolation & purification
Datura metel Daturaterpenoid Sesquiterpenoids Solanaceae

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 16 01 2019
revised: 19 02 2019
accepted: 26 02 2019
pubmed: 3 3 2019
medline: 16 7 2019
entrez: 3 3 2019
Statut: ppublish

Résumé

Four new sesquiterpenoids (1-4) and two known ones (5-6) were isolated and identified from the stems of Datura metel L. The structures of the isolated compounds were established by 1D and 2D NMR spectra, as well as HR-ESI-MS. Additionally, the compounds 1-3 possessed the similar novel skelecton and compounds 5-6 were isolated from the Datura genus for the first time. The hypothetical biogenetic pathway was teased and provided. Meanwhile, the antiproliferative activities were evaluated on the two human cancer cells of HepG2 and Hela, respectively.

Identifiants

DOI: 10.1016/j.fitote.2019.02.029 PMID: 30825573
pubmed: 30825573
pii: S0367-326X(19)30124-8
doi: 10.1016/j.fitote.2019.02.029
pii:
doi:

Substances chimiques

Phytochemicals 0
Sesquiterpenes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

417-421

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Yan Liu (Y)

Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Wei Guan (W)

Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Zhen-Kun Lu (ZK)

Department of Pharmacy, Qingdao NO.6 People's Hospital, Qingdao 266033, China.

Rui Guo (R)

Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Chinese Medicine, Jinzhong 030619, China.

Yong-Gang Xia (YG)

Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Shao-Wa Lv (SW)

Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Bing-You Yang (BY)

Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. Electronic address: ybywater@163.com.

Hai-Xue Kuang (HX)

Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, China. Electronic address: hxkuang@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › New sesquiterpenoids from the stems of Datura metel L.
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Solanales › Solanaceae › Datura › Datura metel › New sesquiterpenoids from the stems of Datura metel L.
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › New sesquiterpenoids from the stems of Datura metel L.
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › New sesquiterpenoids from the stems of Datura metel L.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New sesquiterpenoids from the stems of Datura metel L.
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › New sesquiterpenoids from the stems of Datura metel L.
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › New sesquiterpenoids from the stems of Datura metel L.
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Tiges de plante › New sesquiterpenoids from the stems of Datura metel L.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › New sesquiterpenoids from the stems of Datura metel L.