Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis.

Animals Carbon Tetrachloride Chemical and Drug Induced Liver Injury / etiology Clodronic Acid / pharmacology Collagen Type I / genetics Disease Progression Female Liver / drug effects Liver Cirrhosis, Experimental / chemically induced Mice, Inbred C57BL Monocytes / drug effects Time Factors Up-Regulation
Carbon tetrachloride Clodronate Collagen-I Fibrocytes Liver fibrosis

Journal

Hepatobiliary & pancreatic diseases international : HBPD INT
ISSN: 1499-3872
Titre abrégé: Hepatobiliary Pancreat Dis Int
Pays: Singapore
ID NLM: 101151457

Informations de publication

Date de publication:
Aug 2019
Historique:
received: 14 09 2018
accepted: 15 02 2019
pubmed: 4 3 2019
medline: 11 2 2020
entrez: 4 3 2019
Statut: ppublish

Résumé

Monocyte-derived fibrocytes play an important role in the progression of fibrosis in the skin, lungs, heart and kidney. However, the contribution of fibrocytes to liver fibrosis is unclear. The aim of this study was to investigate whether fibrocytes contributed to fibrosis progression in the livers of carbon tetrachloride (CCl C57BL/6J mice were divided into 4 groups: normal control group, CCl In the liver of the CCl Monocyte-derived fibrocytes play a minimal role in CCl

Sections du résumé

BACKGROUND BACKGROUND
Monocyte-derived fibrocytes play an important role in the progression of fibrosis in the skin, lungs, heart and kidney. However, the contribution of fibrocytes to liver fibrosis is unclear. The aim of this study was to investigate whether fibrocytes contributed to fibrosis progression in the livers of carbon tetrachloride (CCl
METHODS METHODS
C57BL/6J mice were divided into 4 groups: normal control group, CCl
RESULTS RESULTS
In the liver of the CCl
CONCLUSION CONCLUSIONS
Monocyte-derived fibrocytes play a minimal role in CCl

Identifiants

DOI: 10.1016/j.hbpd.2019.02.002 PMID: 30826294
pubmed: 30826294
pii: S1499-3872(19)30029-3
doi: 10.1016/j.hbpd.2019.02.002
pii:
doi:

Substances chimiques

Collagen Type I 0
Clodronic Acid 0813BZ6866
Carbon Tetrachloride CL2T97X0V0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

348-353

Informations de copyright

Copyright © 2019 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.

Auteurs

Yoshinori Ozono (Y)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Kotaro Shide (K)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan. Electronic address: koutaro_shide@med.miyazaki-u.ac.jp.

Fumiyo Toyoshima (F)

Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Yuuka Takaishi (Y)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Mai Tsuchimochi (M)

Department of Liver disease, University of Miyazaki Hospital, Miyazaki, Japan.

Ayako Kamiunten (A)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Takuro Kameda (T)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Kenichi Nakamura (K)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Tadashi Miike (T)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Kazunori Kusumoto (K)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Hisayoshi Iwakiri (H)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Satoru Hasuike (S)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Kenji Nagata (K)

Department of Liver disease, University of Miyazaki Hospital, Miyazaki, Japan.

Akira Sawaguchi (A)

Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan.

Kazuya Shimoda (K)

Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601, Japan; Department of Liver disease, University of Miyazaki Hospital, Miyazaki, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › Tétrachloro-méthane › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › Acide clodronique › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Collagènes fibrillaires › Collagène de type I › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Système digestif › Foie › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Cirrhose expérimentale › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Monocyte-derived fibrocytes elimination had...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Monocyte-derived fibrocytes elimination had...