questionsmedicales.fr
Composés chimiques organiques
Composés organiques du phosphore
Phosphonates
Diphosphonates
Acide clodronique
Acide clodronique : Questions médicales fréquentes
Diagnostic
5
Hypercalcémie
Tests de laboratoire
Métastases osseuses
Imagerie médicale
Douleur osseuse
Fractures
Évaluation du traitement
Tests de laboratoire
Symptômes
5
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Symptômes
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Fractures
Effets secondaires
Acide clodronique
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5
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Acide clodronique
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Acide clodronique
Hypercalcémie
Traitements
Prévention
Acide clodronique
Traitements alternatifs
Bisphosphonates
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5
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Acide clodronique
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Acide clodronique
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Bisphosphonates
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Acide clodronique
Signes d'alerte
Complications graves
Facteurs de risque
5
Facteurs de risque
Hypercalcémie
Antécédents familiaux
Risque osseux
Mode de vie
Risque osseux
Traitements antérieurs
Risque de complications
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"@type": "Question",
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"@type": "Question",
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"position": 10,
"acceptedAnswer": {
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"text": "Des douleurs intenses, des symptômes neurologiques ou des signes d'infection doivent être évalués."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'hypercalcémie chez les patients cancéreux ?",
"position": 11,
"acceptedAnswer": {
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"text": "Une hydratation adéquate et l'utilisation de bisphosphonates comme l'acide clodronique aident."
}
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{
"@type": "Question",
"name": "Quels conseils diététiques pour prévenir l'hypercalcémie ?",
"position": 12,
"acceptedAnswer": {
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"text": "Limiter les aliments riches en calcium et en vitamine D peut aider à prévenir l'hypercalcémie."
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{
"@type": "Question",
"name": "L'exercice physique aide-t-il à prévenir les complications osseuses ?",
"position": 13,
"acceptedAnswer": {
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"text": "Oui, l'exercice régulier renforce les os et peut réduire le risque de fractures."
}
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{
"@type": "Question",
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"position": 14,
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"@type": "Question",
"name": "Comment évaluer le risque de fractures ?",
"position": 15,
"acceptedAnswer": {
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"name": "Comment l'acide clodronique est-il administré ?",
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"name": "Quelle est la posologie standard de l'acide clodronique ?",
"position": 17,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "Quels autres traitements pour l'hypercalcémie ?",
"position": 18,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "L'acide clodronique est-il utilisé en prévention ?",
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{
"@type": "Question",
"name": "Quels sont les traitements alternatifs aux bisphosphonates ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
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}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles de l'acide clodronique ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des douleurs osseuses, des troubles gastro-intestinaux et des réactions allergiques."
}
},
{
"@type": "Question",
"name": "Comment gérer les effets secondaires de l'acide clodronique ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion inclut des ajustements de posologie et des traitements symptomatiques pour les effets secondaires."
}
},
{
"@type": "Question",
"name": "Quels risques d'ostéonécrose avec l'acide clodronique ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'ostéonécrose de la mâchoire est un risque rare mais sérieux associé à l'utilisation de bisphosphonates."
}
},
{
"@type": "Question",
"name": "L'acide clodronique peut-il causer des problèmes rénaux ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surveillance de la fonction rénale est nécessaire, car des problèmes peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels signes d'alerte pour des complications graves ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des douleurs sévères, des gonflements ou des signes d'infection doivent être signalés immédiatement."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'hypercalcémie ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les cancers, les maladies rénales et la déshydratation augmentent le risque d'hypercalcémie."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le risque osseux ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies osseuses peuvent augmenter le risque de complications."
}
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{
"@type": "Question",
"name": "Quel rôle joue l'âge dans le risque de fractures ?",
"position": 28,
"acceptedAnswer": {
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"text": "L'âge avancé est un facteur de risque majeur pour les fractures et la fragilité osseuse."
}
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{
"@type": "Question",
"name": "Le mode de vie affecte-t-il le risque osseux ?",
"position": 29,
"acceptedAnswer": {
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"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque osseux."
}
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"@type": "Question",
"name": "Les traitements antérieurs influencent-ils le risque ?",
"position": 30,
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"@type": "Answer",
"text": "Oui, certains traitements comme les corticostéroïdes peuvent augmenter le risque de complications osseuses."
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 25/03/2026
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
K. L. Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California, Davis, California, USA.
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Dechra Veterinary Products BV, 's-Hertogenbosch, The Netherlands.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
University of Queensland, School of Dentistry, Herston, Queensland, Australia. Electronic address: p.wright1@uq.edu.au.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
University of Queensland, School of Dentistry, Herston, Queensland, Australia.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
University of Queensland, School of Dentistry, Herston, Queensland, Australia.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Istituti Clinici Scientifici Maugeri IRCCS, Rheumatology and Rehabilitation Unit of the Institute of Castel Goffredo, Mantua, Italy.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Department of Animal Science, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Department of Animal Science, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Department of Animal Science, College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, 200237, China.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, 200237, China.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, 200237, China.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, 200237, China.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, 200237, China.
Publications dans "Acide clodronique" :
3 publications dans cette catégorie
Affiliations :
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, 200237, China; Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: chenyz@ecust.edu.cn.
Publications dans "Acide clodronique" :
2 publications dans cette catégorie
Affiliations :
Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Publications dans "Acide clodronique" :
2 publications dans cette catégorie
Affiliations :
GIE-LCH, Laboratoire des Courses Hippiques, Verrières le Buisson, France.
Publications dans "Acide clodronique" :
2 publications dans cette catégorie
Affiliations :
GIE-LCH, Laboratoire des Courses Hippiques, Verrières le Buisson, France.
Publications dans "Acide clodronique" :
Clodronate (Clod), a first-generation bisphosphonate, acts as a natural analgesic inhibiting vesicular storage of the nociception mediator ATP by vesicular nucleotide transporter (VNUT). Epidermal ker...
Clodronic acid is designated as a controlled medication for competition horses by the International Federation for Equestrian Sports and, according to the International Federation of Horseracing Autho...
Helicobacter Pylori (HP) infection could lead to various gastrointestinal diseases. Urease is the most important virulence factor of HP. It protects the bacterium against gastric acid....
Therefore, we aimed to design urease inhibitors as drugs against HP infection....
The DrugBank-approved library was assigned with 3D conformations and the structure of the urease was prepared. Using a re-docking strategy, the proper settings were determined for docking by PyRx and ...
The structures of prepared drugs were screened against urease structure using the determined settings. Clodronic acid was determined to be the best-identified drug, due to higher PyRx binding energy, ...
Clodronic acid has better HP urease inhibition potential than AHA. Given its approved status, the development of a repurposed drug based on Clodronic acid would require less time and cost. Further, in...
There are two FDA-approved bisphosphonate products, clodronate (Osphos®) and tiludronate (Tildren®), for use in horses. It is hypothesized that bisphosphonates can produce analgesic effects and preven...
Bisphosphonates and receptor activator of nuclear factor-kappa B ligand (RANKL)-inhibitors are amongst the bone-modifying agents used as supportive treatment in women with breast cancer who do not hav...
To assess and compare the effects of different bone-modifying agents as supportive treatment to reduce bone mineral density loss and osteoporotic fractures in women with breast cancer without bone met...
We identified studies by electronically searching CENTRAL, MEDLINE and Embase until January 2023. We searched various trial registries and screened abstracts of conference proceedings and reference li...
We included randomised controlled trials comparing different bisphosphonates and RANKL-inihibitors with each other or against no further treatment or placebo for women with breast cancer without bone ...
Two review authors independently extracted data and assessed the risk of bias of included studies and certainty of evidence using GRADE. Outcomes were bone mineral density, quality of life, overall fr...
Forty-seven trials (35,163 participants) fulfilled our inclusion criteria; 34 trials (33,793 participants) could be considered in the NMA (8 different treatment options). Bone mineral density We estim...
When considering bone-modifying agents for managing bone loss in women with early or locally advanced breast cancer, one has to balance between efficacy and safety. Our findings suggest that bisphosph...
Microglial cells have been demonstrated to be significant resident immune cells that maintain homeostasis under physiological conditions. However, prolonged or excessive microglial activation leads to...
Bisphosphonates and myo-inositol trispyrophosphate (ITPP) are two classes of difficult-to-detect polar drugs that are prohibited under the rules of racing. ITPP is a drug capable of increasing the amo...
The dense nerve and thin vascular structure of the corneal tissue provide the refractive function in healthy eyes. Diabetes mellitus causes ocular complications including corneal opacification because...
Radiation-induced lung injury (RILI) is a severe complication arising from thoracic tumor radiotherapy, which constrains the possibility of increasing radiation dosage. Current RILI therapies provide ...
Clodronate-Liposomes (Clod-Lipo) injection after hematopoietic stem cell transplantation (HSCT) has been shown to be detrimental to hematopoietic reconstitution after transplantation, and our previous...
BALB/c mice received 7.5 Gy of total body irradiation followed by infusion of 5x106 bone marrow mononuclear cells from C57BL/6 via the tail vein. Clod-Lipo were injected through the tail vein on the f...
Compared with the other two groups, a significant increase in adipocytes was found in the Clod-Lipo group by HE staining, and increased expression of NLRP3 and Caspase-1 in mouse bone marrow cells was...
The results of this study suggest that MSC are biased towards adipocyte generation in response to Clod-Lipo, a process that may be associated with activation of the NLRP3/caspase-1 pathway....