Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension.
Angiotensinogen
/ metabolism
Animals
Blood Pressure
/ genetics
Cells, Cultured
Collagen Type IV
/ genetics
Disease Models, Animal
Fibrosis
Hepatocytes
Humans
Hypertension
/ etiology
Kidney
/ pathology
Lymphokines
/ antagonists & inhibitors
Male
Mice
Mice, Knockout
Platelet-Derived Growth Factor
/ antagonists & inhibitors
Primary Cell Culture
Up-Regulation
Ureter
/ surgery
PDGF-C
angiotensin
angiotensinogen
hypertension
renal fibrosis
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
26
03
2018
revised:
15
11
2018
accepted:
21
11
2018
pubmed:
5
3
2019
medline:
3
4
2020
entrez:
5
3
2019
Statut:
ppublish
Résumé
Platelet-derived growth factors (PDGF) have been implicated in kidney disease progression. We previously found that PDGF-C is upregulated at sites of renal fibrosis and that antagonism of PDGF-C reduces fibrosis in the unilateral ureteral obstruction model. We studied the role of PDGF-C in collagen 4A3
Identifiants
pubmed: 30827511
pii: S0085-2538(18)30920-7
doi: 10.1016/j.kint.2018.11.031
pii:
doi:
Substances chimiques
Collagen Type IV
0
Lymphokines
0
Platelet-Derived Growth Factor
0
platelet-derived growth factor C
0
Angiotensinogen
11002-13-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1103-1119Informations de copyright
Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.