Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase.
Polyamine analogues
docking studies
inhibitors
polyamine oxidase
spermine oxidase
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
5
3
2019
pubmed:
5
3
2019
medline:
8
5
2019
Statut:
ppublish
Résumé
Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1-9) or methoctramine (10-14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and acetylpolyamine oxidase (PAOX). Compound 2 turned out to be the best substrate for PAOX, having the highest affinity and catalytic efficiency with respect to its physiological substrates. Methoctramine (10), a well-known muscarinic M
Identifiants
pubmed: 30829081
doi: 10.1080/14756366.2019.1584620
pmc: PMC6407594
doi:
Substances chimiques
Diamines
0
Enzyme Inhibitors
0
Polyamines
0
Oxidoreductases Acting on CH-NH Group Donors
EC 1.5.-
methoctramine
NVJ76B897D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
740-752Références
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