Lower 90-day Hospital Readmission Rates for Esophageal Variceal Bleeding After TIPS: A Nationwide Linked Analysis.


Journal

Journal of clinical gastroenterology
ISSN: 1539-2031
Titre abrégé: J Clin Gastroenterol
Pays: United States
ID NLM: 7910017

Informations de publication

Date de publication:
01 2020
Historique:
pubmed: 5 3 2019
medline: 29 4 2021
entrez: 5 3 2019
Statut: ppublish

Résumé

Hospital readmission rates following a transjugular intrahepatic portosystemic shunt (TIPS) insertion after an episode of esophageal variceal bleeding (EVB) has not been well studied. We aimed to address this gap in knowledge on a population level. The Nationwide Readmission Database (NRD) was used to study the readmission rates for patients with decompensated cirrhosis who had a TIPS insertion performed for EVB. The NRD is a national database that tracks patients longitudinally for hospital readmissions. A propensity score matching model was created to match patients who received TIPS with those who did not. A total of 42,679,001 hospital admissions from the 2012 to 2014 NRD sample were analyzed. There were 33,934 patients with EVB who met inclusion criteria for the study, of whom, 1527 (4.5%) received TIPS after EVB and were matched with 1527 patients with EVB who did not undergo TIPS. With a uniform follow-up of 3 months, patients with TIPS were less likely to be readmitted to hospital with a recurrent EVB [odds ratio (OR): 0.33, 95% confidence interval (CI): 0.24-0.47, P<0.01], although were more likely to be readmitted with hepatic encephalopathy (OR: 1.66; 95% CI: 1.31-2.11, P<0.01). At 3 months, there was no difference in all cause hospital readmission rate between the 2 groups (OR: 38.8%; 95% CI: 38.1-44.9 TIPS vs. OR: 41.5%; 95% CI: 34.1-43.3 non-TIPS: P=0.17). In this large nationally representative study, TIPS insertion after an episode of EVB was associated with a significantly lower risk of 3-month readmission for recurrent EVB compared with patients who did not receive TIPS. Although those receiving TIPS had a higher rate of hepatic encephalopathy the overall readmission remained unchanged.

Identifiants

pubmed: 30829905
doi: 10.1097/MCG.0000000000001199
pii: 00004836-202001000-00015
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

90-95

Références

D’Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol. 2006;44:217–231.
Garcia-Tsao G, Friedman S, Iredale J, et al. Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis. Hepatology. 2010;51:1445–1449.
Everhart JE, Ruhl CE. Burden of digestive diseases in the United States Part III: liver, biliary tract, and pancreas. Gastroenterology. 2009;136:1134–1144.
Nguyen GC, Segev DL, Thuluvath PJ. Nationwide increase in hospitalizations and hepatitis C among inpatients with cirrhosis and sequelae of portal hypertension. Clin Gastroenterol Hepatol. 2007;5:1092–1099.
Garcia-Tsao G, Sanyal AJ, Grace ND, et al. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007;46:922–938.
Carbonell N, Pauwels A, Serfaty L, et al. Improved survival after variceal bleeding in patients with cirrhosis over the past two decades. Hepatology. 2004;40:652–659.
Holster IL, Tjwa ET, Moelker A, et al. TIPS superior to endoscopic therapy for variceal bleeding in cirrhosis. Hepatology. 2016;63:581–589.
Jairath V, Rehal S, Logan R, et al. Acute variceal haemorrhage in the United Kingdom: Patient characteristics, management and outcomes in a nationwide audit. Dig Liver Dis. 2014;46:419–426.
De Franchis R. Baveno V Faculty. Revising consensus in portal hypertension: report of the Baveno V Consensus Workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53:762–768.
Laine L, Abid S, Albillos A, et alDe Franchis R. Treatment of acute bleeding. Portal Hypertension V, 5th ed. New Delhi: Blackwell; 2011:103–120.
D’Amico M, Berzigotti A, Garcia-Pagan JC. Refractory acute variceal bleeding: what to do next? Clin Liver Dis. 2010;14:297–305.
Escorsell A, Pavel O, Cardenas A, et al. Variceal bleeding study G: esophageal balloon tamponade versus esophageal stent in controlling acute refractory variceal bleeding: a multicenter randomized, controlled trial. Hepatology. 2016;63:1957–1967.
Holster IL, Tjwa ET, Moelker A, et al. Covered transjugular intrahepatic portosystemic shunt versus endoscopic therapy + B-blocker for prevention of variceal rebleeding. Hepatology. 2016;63:581–589.
Arguedas MR, DeLawrence TG, McGuire BM. Influence of hepatic encephalopathy on health-related quality of life in patients with cirrhosis. Dig Dis Sci. 2003;48:1622–1626.
Tapper EB, Halbert B, Mellinger J. Rates of and reasons for hospital readmissions in patients with cirrhosis: a multistate population-based cohort study. Clin Gastroenterol Hepatol. 2016;14:1181–1188.
Volk ML, Tocco RS, Bazick J, et al. Hospital re-admissions among patients with decompensated cirrhosis. Am J Gastroenterol. 2012;107:247–252.
Singal AG, Rahimi RS, Clark C, et al. An automated model using electronic medical record data identifies patients with cirrhosis at high risk for readmission. Clin Gastroenterol Hepatol. 2013;11:1335–1341.
Vandenbroucke JP, von Elm E, Altman DG, et al. Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. Epidemiology. 2007;18:805–835.
Agency for Healthcare Research and Quality (AHRQ). National Readmission Database—Agency for Healthcare Research and Quality. 2017. Available at: www.hcup-us.ahrq.gov/nrdoverview.jsp. Accessed September 1, 2017.
Goldberg D, Lewis J, Halpern S, et al. Validation of three coding algorithms to identify patients with end-stage liver disease in an administrative database. Pharmacoepidemiol Drug Saf. 2012;21:765–769.
Garcia-Tsao G, Bosch J. Varices and variceal hemorrhage in cirrhosis: a new view of an old problem. Clin Gastroenterol Hepatol. 2015;13:2109–2117.
Puente A, Hernandez-Gea V, Graupera I, et al. Drugs plus ligation to prevent rebleeding in cirrhosis: an updated systematic review. Liver Int. 2014;34:823–833.
Monescillo A, Martinez-Lagares F, Ruize-del-Arbol L, et al. Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding. Hepatology. 2004;40:793–801.
Bueau C, Garcia-Pagan JC, Oral P, et al. Improved clinical outcome using polytetrafluoroethylene-coated stents for TIPS: results of a randomized study. Gastroenterology. 2004;126:469–475.
Garcia-Pagan JC, Caca K, Bureau C, et al. Early use of TIPS in patients with Cirrhosis and Variceal Bleeding. N Engl J Med. 2010;362:2370–2379.
Bucsics T, Schoder M, Goeschl N, et al. Re-bleeding rates and survival after early transjugular intrahepatic portosystemic shunt (TIPS) in clinical practice. Dig Liver Dis. 2017;49:1360–1367.
Tapper EB, Finkelstein D, Mittleman MA, et al. A quality improvement initiative reduces 30-day rate of readmission for patients with cirrhosis. Clin Gastroenterol Hepatol. 2016;14:753–759.

Auteurs

Barret Rush (B)

Department of Medicine, Division of Critical Care Medicine, St. Paul's Hospital.

Navjot Deol (N)

Department of Medicine, Division of Gastroenterology, London Health Sciences Center.

Anour Teriyaki (A)

Department of Medicine, Division of Gastroenterology, London Health Sciences Center.

Michael Sey (M)

Department of Medicine, Division of Gastroenterology, London Health Sciences Center.

Vipul Jairath (V)

Department of Medicine, Division of Gastroenterology, London Health Sciences Center.
Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.

Keith R Walley (KR)

Department of Medicine, Division of Critical Care Medicine, St. Paul's Hospital.
Center for Heart Lung Innovation (HLI), University of British Columbia, Vancouver, BC.

Leo A Celi (LA)

Department of Medicine, Division of Critical Care Medicine, Beth Israel Deaconess Medical Center.
Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA.

Mayur Brahmania (M)

Department of Medicine, Division of Gastroenterology, London Health Sciences Center.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH