Characterization of Reston virus infection in ferrets.

Animals Disease Models, Animal Ebolavirus / pathogenicity Ferrets / virology Filoviridae Infections / pathology Liver / pathology Spleen / pathology Viral Load Viremia
Ebolavirus Ferret Lethal disease Reston virus

Journal

Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699

Informations de publication

Date de publication:
05 2019
Historique:
received: 09 12 2018
revised: 28 02 2019
accepted: 01 03 2019
pubmed: 6 3 2019
medline: 9 4 2020
entrez: 6 3 2019
Statut: ppublish

Résumé

Among the five currently recognized type viruses within the genus Ebolavirus, Reston virus (RESTV) is not known to cause disease in humans, although asymptomatic infections have been confirmed in the past. Intriguingly, despite the absence of pathogenicity in humans, RESTV is highly lethal to nonhuman primates and has been isolated from domestic pigs co-infected with other viruses in the Philippines and China. Whether infection in these animals can support the eventual emergence of a human-pathogenic RESTV remains unclear and requires further investigation. Unfortunately, there is currently no lethal small animal model available to investigate RESTV pathogenicity or pan-ebolavirus therapeutics. Here we show that wild type RESTV is uniformly lethal in ferrets. In this study, ferrets were challenged with 1260 TCID

Identifiants

DOI: 10.1016/j.antiviral.2019.03.001 PMID: 30836107
pubmed: 30836107
pii: S0166-3542(18)30730-7
doi: 10.1016/j.antiviral.2019.03.001
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-10

Subventions

Organisme : NIAID NIH HHS
ID : U19 AI109762
Pays : United States

Informations de copyright

Crown Copyright © 2019. Published by Elsevier B.V. All rights reserved.

Auteurs

Feihu Yan (F)

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada; Key Laboratory of Jilin Province for Zoonosis Prevention and Control in Key Lab, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.

Shihua He (S)

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

Logan Banadyga (L)

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

Wenjun Zhu (W)

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

Huajun Zhang (H)

Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

Md Niaz Rahim (MN)

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

Brad Collignon (B)

Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada.

Chandrika Senthilkumaran (C)

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

Carissa Embury-Hyatt (C)

Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, Manitoba, Canada.

Xiangguo Qiu (X)

Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: xiangguo.qiu@canada.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Characterization of Reston virus infection in ferrets.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Characterization of Reston virus infection in ferrets.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Mononegavirales › Filoviridae › Ebolavirus › Characterization of Reston virus infection in ferrets.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Mustelidae › Furets › Characterization of Reston virus infection in ferrets.
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Mononegavirales › Infections à Filoviridae › Characterization of Reston virus infection in ferrets.
questionsmedicales.fr › Système digestif › Foie › Characterization of Reston virus infection in ferrets.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › Characterization of Reston virus infection in ferrets.
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Characterization of Reston virus infection in ferrets.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Virémie › Characterization of Reston virus infection in ferrets.