Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 03 2019
05 03 2019
Historique:
received:
15
08
2018
accepted:
30
01
2019
entrez:
7
3
2019
pubmed:
7
3
2019
medline:
6
4
2019
Statut:
epublish
Résumé
Sleep is essential to all animals with a nervous system. Nevertheless, the core cellular function of sleep is unknown, and there is no conserved molecular marker to define sleep across phylogeny. Time-lapse imaging of chromosomal markers in single cells of live zebrafish revealed that sleep increases chromosome dynamics in individual neurons but not in two other cell types. Manipulation of sleep, chromosome dynamics, neuronal activity, and DNA double-strand breaks (DSBs) showed that chromosome dynamics are low and the number of DSBs accumulates during wakefulness. In turn, sleep increases chromosome dynamics, which are necessary to reduce the amount of DSBs. These results establish chromosome dynamics as a potential marker to define single sleeping cells, and propose that the restorative function of sleep is nuclear maintenance.
Identifiants
pubmed: 30837464
doi: 10.1038/s41467-019-08806-w
pii: 10.1038/s41467-019-08806-w
pmc: PMC6401120
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
895Commentaires et corrections
Type : CommentIn
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