Potassium-sparing effects of furosemide in mice on high-potassium diets.
BK
ROMK
furosemide
high-K diet
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
pubmed:
7
3
2019
medline:
30
1
2020
entrez:
7
3
2019
Statut:
ppublish
Résumé
In individuals on a regular "Western" diet, furosemide induces a kaliuresis and reduction in plasma K concentration by inhibiting Na reabsorption in the thick ascending limb of Henle's loop, enhancing delivery of Na to the aldosterone-sensitive distal nephron. In the aldosterone-sensitive distal nephron, the increased Na delivery stimulates K wasting due to an exaggerated exchange of epithelial Na channel-mediated Na reabsorption of secreted K. The effects of furosemide are different in mice fed a high-K, alkaline (HK) diet: the large-conductance Ca-activated K (BK) channel, in conjunction with the BK β
Identifiants
pubmed: 30838871
doi: 10.1152/ajprenal.00614.2018
pmc: PMC6580254
doi:
Substances chimiques
Diuretics, Potassium Sparing
0
Kcnj1 protein, mouse
0
Large-Conductance Calcium-Activated Potassium Channels
0
Potassium Channels, Inwardly Rectifying
0
Potassium, Dietary
0
Furosemide
7LXU5N7ZO5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
F970-F973Subventions
Organisme : NIDDK NIH HHS
ID : F30 DK108456
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK071014
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK092474
Pays : United States
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