Congenital toxoplasmosis in the United States: clinical and serologic findings in infants born to mothers treated during pregnancy.
Toxoplasmose congénitale aux États-Unis : observations cliniques et sérologiques chez les nourrissons nés de mères traitées pendant la grossesse.
Antibodies, Protozoan
/ blood
Clinical Laboratory Techniques
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hydrocephalus
/ epidemiology
Immunoglobulin G
/ blood
Immunoglobulin M
/ blood
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical
/ prevention & control
Male
Mothers
Pregnancy
Pregnancy Complications, Parasitic
/ drug therapy
Retrospective Studies
Sensitivity and Specificity
Serologic Tests
Toxoplasmosis, Congenital
/ blood
United States
/ epidemiology
Journal
Parasite (Paris, France)
ISSN: 1776-1042
Titre abrégé: Parasite
Pays: France
ID NLM: 9437094
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
01
2019
accepted:
21
02
2019
entrez:
7
3
2019
pubmed:
7
3
2019
medline:
19
3
2019
Statut:
ppublish
Résumé
We assessed clinical and serologic findings in 25 infants with congenital toxoplasmosis born to mothers treated during pregnancy in the United States. Results indicate a lower prevalence of eye findings and hydrocephalus in the group of infants born to treated mothers (62.5% and 38.5%, respectively) compared to results on the same pathologies reported in our previous cohort of infants born to untreated mothers (92.2% and 67.7%, respectively). The sensitivity of the IgM ISAGA and IgA ELISA in the present study were lower (44% and 60%, respectively) compared to sensitivity of these methods in our previously studied group of infants born to untreated mothers (86.6% and 76.5%, respectively). These findings provide further evidence that anti-parasitic treatment if administered during pregnancy can contribute to better clinical outcomes, even in countries where systematic screening and treatment have not been routinely implemented.
Identifiants
pubmed: 30838974
doi: 10.1051/parasite/2019013
pii: parasite190002
pmc: PMC6402364
doi:
Substances chimiques
Antibodies, Protozoan
0
Immunoglobulin G
0
Immunoglobulin M
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13Informations de copyright
© T.R. Olariu, published by EDP Sciences, 2019.
Références
J Pediatr. 1999 Dec;135(6):714-9
pubmed: 10586174
J Infect Dis. 2002 Feb 15;185 Suppl 1:S73-82
pubmed: 11865443
Lancet. 2007 Jan 13;369(9556):115-22
pubmed: 17223474
Pediatr Infect Dis J. 2008 Jan;27(1):27-32
pubmed: 18162934
Euro Surveill. 2010 Jun 24;15(25):null
pubmed: 20587361
PLoS Med. 2010 Oct 12;7(10):null
pubmed: 20967235
Pediatr Infect Dis J. 2011 Dec;30(12):1056-61
pubmed: 21956696
J Clin Microbiol. 1990 Oct;28(10):2297-301
pubmed: 2229355
Clin Infect Dis. 2012 Jun;54(11):1545-52
pubmed: 22460980
Clin Infect Dis. 2013 May;56(9):1223-31
pubmed: 23362291
BMC Infect Dis. 2014 Jan 18;14:33
pubmed: 24438336
Pediatr Infect Dis J. 2014 Jun;33(6):566-70
pubmed: 24445828
Clin Infect Dis. 2015 Jan 15;60(2):e4-e10
pubmed: 25216688
Am J Obstet Gynecol. 2018 Oct;219(4):315-319
pubmed: 30269768
N Engl J Med. 1974 May 16;290(20):1110-6
pubmed: 4821174