Inactivating Mutation in IRF8 Promotes Osteoclast Transcriptional Programs and Increases Susceptibility to Tooth Root Resorption.
Aged, 80 and over
Animals
Female
Genetic Predisposition to Disease
Humans
Interferon Regulatory Factors
/ chemistry
Interferon-gamma
/ pharmacology
Jaw
/ pathology
Lipopolysaccharides
/ pharmacology
Macrophages
/ drug effects
Male
Mice
Middle Aged
Mutation
/ genetics
Osteoclasts
/ drug effects
Osteogenesis
/ drug effects
Pedigree
Root Resorption
/ genetics
Signal Transduction
/ drug effects
Transcription, Genetic
/ drug effects
Transcriptome
/ genetics
DENTAL BIOLOGY
EPIGENETICS
OSTEOCLASTS
OSTEOIMMUNOLOGY
OSTEOPOROSIS
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
17
10
2018
revised:
14
01
2019
accepted:
26
01
2019
pubmed:
7
3
2019
medline:
7
8
2020
entrez:
7
3
2019
Statut:
ppublish
Résumé
This is the first study to our knowledge to report a novel mutation in the interferon regulatory factor 8 gene (IRF8
Identifiants
pubmed: 30840779
doi: 10.1002/jbmr.3690
pmc: PMC6663587
mid: NIHMS1020165
doi:
Substances chimiques
Interferon Regulatory Factors
0
Lipopolysaccharides
0
interferon regulatory factor-8
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1155-1168Subventions
Organisme : NIAMS NIH HHS
ID : R00 AR066110
Pays : United States
Organisme : NIDCR NIH HHS
ID : R00 DE028439
Pays : United States
Informations de copyright
© 2019 American Society for Bone and Mineral Research.
Références
Immunity. 2000 Aug;13(2):155-65
pubmed: 10981959
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5798-803
pubmed: 11331755
J Interferon Cytokine Res. 2002 Jan;22(1):145-52
pubmed: 11846985
Blood. 2003 Jan 1;101(1):305-10
pubmed: 12393690
Nature. 2003 May 15;423(6937):337-42
pubmed: 12748652
Nat Genet. 2003 Jul;34(3):267-73
pubmed: 12808457
Dent Traumatol. 2003 Aug;19(4):175-82
pubmed: 12848710
Dentomaxillofac Radiol. 2003 May;32(3):150-5
pubmed: 12917279
Nat Struct Biol. 2003 Nov;10(11):922-7
pubmed: 14555995
Nat Struct Biol. 2003 Nov;10(11):913-21
pubmed: 14555996
Am J Hum Genet. 2004 Sep;75(3):410-23
pubmed: 15257518
Structure. 2005 Sep;13(9):1269-77
pubmed: 16154084
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
J Interferon Cytokine Res. 2005 Dec;25(12):770-9
pubmed: 16375605
J Immunol. 2006 Jan 15;176(2):880-8
pubmed: 16393972
J Biol Chem. 2006 Apr 14;281(15):10073-80
pubmed: 16484229
Mol Immunol. 2007 Jan;44(4):338-46
pubmed: 16597464
J Periodontol. 2007 Feb;78(2):367-71
pubmed: 17274728
Nat Biotechnol. 2007 Mar;25(3):285-6
pubmed: 17344875
J Oral Sci. 2007 Mar;49(1):1-12
pubmed: 17429176
Nat Protoc. 2007;2(4):924-32
pubmed: 17446874
J Immunol. 2007 Aug 15;179(4):2467-76
pubmed: 17675508
Blood. 2008 Feb 15;111(4):1942-5
pubmed: 18055870
Nat Struct Mol Biol. 2008 Nov;15(11):1213-20
pubmed: 18836453
J Immunol. 2009 Mar 1;182(5):3008-15
pubmed: 19234196
Nat Genet. 2009 Jul;41(7):776-82
pubmed: 19525953
Nat Med. 2009 Sep;15(9):1066-71
pubmed: 19718038
Cell Signal. 2010 Jun;22(6):883-7
pubmed: 20043992
Nat Biotechnol. 2010 May;28(5):495-501
pubmed: 20436461
J Bone Miner Res. 2010 Jul;25(7):1468-86
pubmed: 20533309
N Engl J Med. 2011 Jul 14;365(2):127-38
pubmed: 21524210
N Engl J Med. 2011 Aug 18;365(7):611-9
pubmed: 21793738
PLoS Genet. 2011 Oct;7(10):e1002341
pubmed: 22046141
J Exp Med. 2012 Feb 13;209(2):319-34
pubmed: 22249448
EMBO J. 2013 May 15;32(10):1478-88
pubmed: 23584533
Periodontol 2000. 2014 Feb;64(1):57-80
pubmed: 24320956
Immunity. 2014 Feb 20;40(2):187-98
pubmed: 24485804
Nat Commun. 2014;5:3303
pubmed: 24526256
J Cell Mol Med. 2014 Aug;18(8):1588-98
pubmed: 24954358
Blood. 2014 Sep 18;124(12):1894-904
pubmed: 25122610
Cell Res. 2014 Nov;24(11):1311-27
pubmed: 25312340
Nat Commun. 2014 Nov 13;5:5418
pubmed: 25391636
Genes Dev. 2015 Feb 15;29(4):394-408
pubmed: 25637355
J Periodontol. 2015 May;86(5):611-22
pubmed: 25688694
Nat Med. 2015 Mar;21(3):281-7
pubmed: 25706873
Nat Protoc. 2015 Jun;10(6):845-58
pubmed: 25950237
J Immunol. 2016 Feb 15;196(4):1666-77
pubmed: 26746189
J Exp Med. 2016 Apr 4;213(4):585-603
pubmed: 27001747
Nucleic Acids Res. 2016 Jul 8;44(W1):W160-5
pubmed: 27079975
J Clin Invest. 2017 Jan 3;127(1):306-320
pubmed: 27893462
J Allergy Clin Immunol. 2018 Jun;141(6):2234-2248
pubmed: 29128673
Czas Stomatol. 1966 Feb;19(2):161-5
pubmed: 5219995
J Biol Chem. 1995 Jun 2;270(22):13063-9
pubmed: 7768900
Proc Natl Acad Sci U S A. 1994 May 24;91(11):5046-50
pubmed: 8197182