Sitagliptin and shock wave-supported peripheral blood derived endothelial progenitor cell therapy effectively preserves residual renal function in chronic kidney disease in rat-role of dipeptidyl peptidase 4 inhibition.
Animals
Biomarkers
/ metabolism
Cell- and Tissue-Based Therapy
/ methods
Creatinine
/ metabolism
Dipeptidyl Peptidase 4
/ metabolism
Dipeptidyl-Peptidase IV Inhibitors
/ pharmacology
Endothelial Progenitor Cells
/ metabolism
Glucagon-Like Peptide 1
/ metabolism
Hypoglycemic Agents
/ pharmacology
Kidney
/ drug effects
Male
Oxidative Stress
/ drug effects
Proteinuria
/ drug therapy
Rats
Rats, Sprague-Dawley
Renal Insufficiency, Chronic
/ drug therapy
Sitagliptin Phosphate
/ pharmacology
Chronic kidney disease
Endothelial progenitor cells
High-protein diet
Shock wave
Sitagliptin
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
11
11
2018
revised:
02
01
2019
accepted:
06
01
2019
entrez:
8
3
2019
pubmed:
8
3
2019
medline:
22
6
2019
Statut:
ppublish
Résumé
This study tested whether sitagliptin and shock wave (SW)-assisted circulatory-derived autologous endothelial progenitor cell (EPC) therapy would effectively preserve residual renal function in chronic kidney disease (CKD) induced by 5/6 left-nephrectomy/remove right kidney plus daily feeding high-protein diet (H
Identifiants
pubmed: 30841422
pii: S0753-3322(18)38000-4
doi: 10.1016/j.biopha.2019.01.025
pii:
doi:
Substances chimiques
Biomarkers
0
Dipeptidyl-Peptidase IV Inhibitors
0
Hypoglycemic Agents
0
Glucagon-Like Peptide 1
89750-14-1
Creatinine
AYI8EX34EU
Dipeptidyl Peptidase 4
EC 3.4.14.5
Sitagliptin Phosphate
TS63EW8X6F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1088-1102Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved.