Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors.
Adenoma
/ diagnosis
Adrenal Cortex Neoplasms
/ diagnosis
Adrenocortical Carcinoma
/ diagnosis
Aged
Aged, 80 and over
Biomarkers, Tumor
/ metabolism
Cell Cycle Proteins
/ metabolism
Cell Proliferation
Female
Humans
Ki-67 Antigen
/ metabolism
Male
Middle Aged
Minichromosome Maintenance Complex Component 3
/ metabolism
Minichromosome Maintenance Complex Component 7
/ metabolism
Adrenocortical adenoma
Ki-67
MCM-3
MCM-5
MCM-7
adrenocortical carcinoma
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
14
01
2019
revised:
26
01
2019
accepted:
28
01
2019
entrez:
8
3
2019
pubmed:
8
3
2019
medline:
12
3
2019
Statut:
ppublish
Résumé
Morphological features, combined with Ki-67 proliferative index, remain the standard for discriminating benign and malignant adrenocortical tumors. The aim of this study was to evaluate the role of minichromosome maintenance proteins MCM-3, MCM-5, MCM-7, and Ki-67 as proliferative markers in adrenocortical tumors. Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67. Malignant tumors were characterized by a greater size (p=0.017), volume (p=0.017), and higher levels of Ki-67 (p=0.005), MCM-3 (p=0.005), MCM-7 (p=0.008), but not MCM-5 (p=0.069). The markers' levels were independent from the tumors' size and volume, the patient's age and hormonal status. ROC curves showed Ki-67 (AUC 0.984), MCM-3 (AUC 0.984), and MCM-7 (AUC 0.950), but not MCM-5 (AUC 0.820) to be reliable markers. Ki-67, MCM-3, and MCM-7, but not MCM-5 are reliable proliferative and diagnostic markers in discerning benign and malignant adrenocortical tumors.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Morphological features, combined with Ki-67 proliferative index, remain the standard for discriminating benign and malignant adrenocortical tumors. The aim of this study was to evaluate the role of minichromosome maintenance proteins MCM-3, MCM-5, MCM-7, and Ki-67 as proliferative markers in adrenocortical tumors.
MATERIALS AND METHODS
METHODS
Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67.
RESULTS
RESULTS
Malignant tumors were characterized by a greater size (p=0.017), volume (p=0.017), and higher levels of Ki-67 (p=0.005), MCM-3 (p=0.005), MCM-7 (p=0.008), but not MCM-5 (p=0.069). The markers' levels were independent from the tumors' size and volume, the patient's age and hormonal status. ROC curves showed Ki-67 (AUC 0.984), MCM-3 (AUC 0.984), and MCM-7 (AUC 0.950), but not MCM-5 (AUC 0.820) to be reliable markers.
CONCLUSION
CONCLUSIONS
Ki-67, MCM-3, and MCM-7, but not MCM-5 are reliable proliferative and diagnostic markers in discerning benign and malignant adrenocortical tumors.
Identifiants
pubmed: 30842144
pii: 39/3/1151
doi: 10.21873/anticanres.13224
doi:
Substances chimiques
Biomarkers, Tumor
0
Cell Cycle Proteins
0
Ki-67 Antigen
0
MCM3 protein, human
0
MCM5 protein, human
0
MCM7 protein, human
EC 3.6.4.12
Minichromosome Maintenance Complex Component 3
EC 3.6.4.12
Minichromosome Maintenance Complex Component 7
EC 3.6.4.12
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1151-1159Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.