Predictive value of conventional MRI parameters in first spinal attacks of neuromyelitis optica spectrum disorder.
Adult
Aquaporin 4
/ immunology
Autoantibodies
/ blood
Black People
Caribbean Region
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
/ standards
Male
Middle Aged
Neuromyelitis Optica
/ diagnostic imaging
Plasma Exchange
Predictive Value of Tests
Retrospective Studies
Severity of Illness Index
Spinal Cord
/ diagnostic imaging
MRI
Neuromyelitis optica
disability
plasma exchange
spinal cord
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
8
3
2019
medline:
8
5
2021
entrez:
8
3
2019
Statut:
ppublish
Résumé
While spinal cord (SC) attacks of neuromyelitis optica spectrum disorder (NMOSD) are often devastating, signs predictive of their poor clinical outcome have been elusive until now, except for the delay in initiating plasma exchange (PE). We studied the correlation between conventional non-standardized magnetic resonance imaging (MRI) parameters, PE treatment, and clinical data obtained at nadir and recovery. Retrospective study of first SC attacks of NMOSD. Sixty-nine Afro-Caribbean NMOSD patients were included (aquaporin-4 (AQP4) antibodies positive in 65%). Median nadir and residual expanded disability status score (EDSS) were, respectively, 7.5 and 4.0. In bivariate analysis, all conventional MRI parameters were correlated with nadir and residual EDSS. In multivariate analysis, nadir EDSS correlated with lesion length ( A specific pattern of lesions in conventional MRI data is differentially associated with nadir and residual EDSS. Lesions associated with poor prognosis should prompt highly efficient treatment.
Sections du résumé
BACKGROUND
While spinal cord (SC) attacks of neuromyelitis optica spectrum disorder (NMOSD) are often devastating, signs predictive of their poor clinical outcome have been elusive until now, except for the delay in initiating plasma exchange (PE).
OBJECTIVE
We studied the correlation between conventional non-standardized magnetic resonance imaging (MRI) parameters, PE treatment, and clinical data obtained at nadir and recovery.
METHODS
Retrospective study of first SC attacks of NMOSD.
RESULTS
Sixty-nine Afro-Caribbean NMOSD patients were included (aquaporin-4 (AQP4) antibodies positive in 65%). Median nadir and residual expanded disability status score (EDSS) were, respectively, 7.5 and 4.0. In bivariate analysis, all conventional MRI parameters were correlated with nadir and residual EDSS. In multivariate analysis, nadir EDSS correlated with lesion length (
CONCLUSION
A specific pattern of lesions in conventional MRI data is differentially associated with nadir and residual EDSS. Lesions associated with poor prognosis should prompt highly efficient treatment.
Identifiants
pubmed: 30843448
doi: 10.1177/1352458519834857
doi:
Substances chimiques
AQP4 protein, human
0
Aquaporin 4
0
Autoantibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM