Europium labeled lactosylated albumin as a model workflow for the development of biotherapeutics.

Agglutinins / metabolism Animals Europium / chemistry Female Glycosylation Hep G2 Cells Humans Lactose / chemistry Mice, Inbred BALB C Ricin / metabolism Serum Albumin, Human / chemistry Staining and Labeling Tissue Distribution
Bioconjugates development Lanthanide chelates Nanomedicines Targeted imaging Time resolved fluorescence

Journal

Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142

Informations de publication

Date de publication:
06 2019
Historique:
received: 16 10 2018
revised: 12 02 2019
accepted: 12 02 2019
pubmed: 8 3 2019
medline: 4 12 2019
entrez: 8 3 2019
Statut: ppublish

Résumé

Lactosylated albumin is currently used as a radiopharmaceutical agent to image the liver asialoglycoprotein receptors and quantify hepatic liver function in various diseases. A lactosylated protein (LACTAL) conjugate showed excellent liver uptake compared to non-lactosylated protein and a high signal to noise ratio, based on the biodistribution in mice using

Identifiants

DOI: 10.1016/j.nano.2019.02.011 PMID: 30844577
pubmed: 30844577
pii: S1549-9634(19)30042-5
doi: 10.1016/j.nano.2019.02.011
pii:
doi:

Substances chimiques

Agglutinins 0
Europium 444W947O8O
Ricin 9009-86-3
Lactose J2B2A4N98G
Serum Albumin, Human ZIF514RVZR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

21-30

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Hugo Salmon (H)

Chemical and Biological Technologies for Health (UTCBS), CNRS UMR8258, INSERM U1022, Paris Descartes University, Sorbonne-Paris-Cité, Chimie ParisTech, PSL Research University, School of Pharmacy, Paris, France.

Rabah Gahoual (R)

Chemical and Biological Technologies for Health (UTCBS), CNRS UMR8258, INSERM U1022, Paris Descartes University, Sorbonne-Paris-Cité, Chimie ParisTech, PSL Research University, School of Pharmacy, Paris, France.

Pascal Houzé (P)

Chemical and Biological Technologies for Health (UTCBS), CNRS UMR8258, INSERM U1022, Paris Descartes University, Sorbonne-Paris-Cité, Chimie ParisTech, PSL Research University, School of Pharmacy, Paris, France; Laboratoire de Biochimie, Hôpital Universitaire Necker-Enfants malades, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Tayssir Ibrahim (T)

Chemical and Biological Technologies for Health (UTCBS), CNRS UMR8258, INSERM U1022, Paris Descartes University, Sorbonne-Paris-Cité, Chimie ParisTech, PSL Research University, School of Pharmacy, Paris, France.

Michel Bessodes (M)

Chemical and Biological Technologies for Health (UTCBS), CNRS UMR8258, INSERM U1022, Paris Descartes University, Sorbonne-Paris-Cité, Chimie ParisTech, PSL Research University, School of Pharmacy, Paris, France.

Daniel Scherman (D)

Chemical and Biological Technologies for Health (UTCBS), CNRS UMR8258, INSERM U1022, Paris Descartes University, Sorbonne-Paris-Cité, Chimie ParisTech, PSL Research University, School of Pharmacy, Paris, France.

Johanne Seguin (J)

Chemical and Biological Technologies for Health (UTCBS), CNRS UMR8258, INSERM U1022, Paris Descartes University, Sorbonne-Paris-Cité, Chimie ParisTech, PSL Research University, School of Pharmacy, Paris, France; Optical imaging platform LIOPA, Life imaging, PIV, Faculty of Pharmacy, Paris Descartes University, Paris, France.

Nathalie Mignet (N)

Chemical and Biological Technologies for Health (UTCBS), CNRS UMR8258, INSERM U1022, Paris Descartes University, Sorbonne-Paris-Cité, Chimie ParisTech, PSL Research University, School of Pharmacy, Paris, France. Electronic address: nathalie.mignet@parisdescartes.fr.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Coagulants › Agglutinines › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Eucaryotes › Animaux › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Terres rares › Lanthanides › Europium › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Glycosylation › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Glucides › Sucres › Diholoside › Lactose › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Lectines végétales › Ricine › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Sérum-albumine humaine › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Techniques histologiques › Techniques de préparation histocytologique › Coloration et marquage › Europium labeled lactosylated albumin as a...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Europium labeled lactosylated albumin as a...