Evaluation of the Estimation of Physiologic Ability and Surgical Stress Score as a Prognostic Indicator for Older Patients with Gastric Cancer.
Adenocarcinoma
/ mortality
Aged
Aged, 80 and over
Female
Follow-Up Studies
Gastrectomy
Health Status Indicators
Humans
Male
Neoplasm Recurrence, Local
/ epidemiology
Perioperative Care
/ methods
Postoperative Complications
/ epidemiology
Prognosis
ROC Curve
Retrospective Studies
Risk Assessment
Stomach Neoplasms
/ mortality
Stress, Physiological
Survival Analysis
Aged
Estimation of physiologic ability and surgical stress
Gastric cancer
Prognosis
Journal
Digestive surgery
ISSN: 1421-9883
Titre abrégé: Dig Surg
Pays: Switzerland
ID NLM: 8501808
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
09
2018
accepted:
30
01
2019
pubmed:
8
3
2019
medline:
2
12
2020
entrez:
8
3
2019
Statut:
ppublish
Résumé
The incidence of gastric cancer (GC) among the older adults is increasing. Therefore, determining postoperative age-associated prognostic factors is clinically important. This present study retrospectively investigated the prognostic significance of the estimation of physiologic ability and surgical stress (E-PASS) of such patients with GC. We enrolled 136 patients aged ≥75 years with a histopathological diagnosis of gastric adenocarcinoma who underwent gastrectomy. Receiver operating characteristic curves were generated to evaluate survival, and AUC values were compared to assess the discriminatory ability of carcinoembryonic antigen, the perioperative risk score, the surgical stress score, and the comprehensive risk score (CRS) of E-PASS. The AUC value of CRS was of the highest AUC value as a function of overall survival (OS) and disease-specific survival. The 5-year OS rates of CRSHigh and CRSLow groups were 50.6 and 76.9% (p = 0.0007) respectively. The 5-year DSS rates of the CRSHigh and CRSLow groups were 78.8 and 95.2% (p = 0.028) respectively. Further, the 5-year survival rates unrelated to cancer of the CRSHigh and CRSLow groups were 64.2 and 80.9% (p = 0.0096) respectively. Multivariate analysis identified that CRS was an independent prognostic indicator. E-PASS was a useful prognostic indicator for older GC patients.
Sections du résumé
BACKGROUND
BACKGROUND
The incidence of gastric cancer (GC) among the older adults is increasing. Therefore, determining postoperative age-associated prognostic factors is clinically important. This present study retrospectively investigated the prognostic significance of the estimation of physiologic ability and surgical stress (E-PASS) of such patients with GC.
METHODS
METHODS
We enrolled 136 patients aged ≥75 years with a histopathological diagnosis of gastric adenocarcinoma who underwent gastrectomy.
RESULTS
RESULTS
Receiver operating characteristic curves were generated to evaluate survival, and AUC values were compared to assess the discriminatory ability of carcinoembryonic antigen, the perioperative risk score, the surgical stress score, and the comprehensive risk score (CRS) of E-PASS. The AUC value of CRS was of the highest AUC value as a function of overall survival (OS) and disease-specific survival. The 5-year OS rates of CRSHigh and CRSLow groups were 50.6 and 76.9% (p = 0.0007) respectively. The 5-year DSS rates of the CRSHigh and CRSLow groups were 78.8 and 95.2% (p = 0.028) respectively. Further, the 5-year survival rates unrelated to cancer of the CRSHigh and CRSLow groups were 64.2 and 80.9% (p = 0.0096) respectively. Multivariate analysis identified that CRS was an independent prognostic indicator.
CONCLUSIONS
CONCLUSIONS
E-PASS was a useful prognostic indicator for older GC patients.
Identifiants
pubmed: 30844794
pii: 000497457
doi: 10.1159/000497457
doi:
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
171-178Informations de copyright
© 2019 S. Karger AG, Basel.