The synthetic cathinone psychostimulant α-PPP antagonizes serotonin 5-HT
2,5-dimethoxy-4-iodoamphetamine (DOI)
5-HT2A
cathinone
psychostimulant
α-pyrrolidinopropiophenone (α-PPP)
Journal
Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
21
12
2018
revised:
26
02
2019
accepted:
27
02
2019
pubmed:
8
3
2019
medline:
22
1
2020
entrez:
8
3
2019
Statut:
ppublish
Résumé
Synthetic cathinones (SCs) are β-keto analogs of amphetamines. Like amphetamines, SCs target monoamine transporters; however, unusual neuropsychiatric symptoms have been associated with abuse of some SCs, suggesting SCs might possess additional pharmacological properties. We performed radioligand competition binding assays to assess the affinities of nine SCs at human 5-HT
Identifiants
pubmed: 30845376
doi: 10.1002/dta.2582
pmc: PMC6615953
mid: NIHMS1031463
doi:
Substances chimiques
Alkaloids
0
Central Nervous System Stimulants
0
Propiophenones
0
Pyrrolidines
0
Receptor, Serotonin, 5-HT2A
0
Serotonin 5-HT2 Receptor Antagonists
0
alpha-pyrrolidinopropiophenone
01DP8CH58H
cathinone
540EI4406J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
990-998Subventions
Organisme : NIDA NIH HHS
ID : R21 DA040907
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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