The Role of Tocotrienol in Protecting Against Metabolic Diseases.
Adipogenesis
/ drug effects
Animals
Humans
Hypoglycemic Agents
/ chemistry
Inflammation
/ prevention & control
Insulin Resistance
Lipid Metabolism
/ drug effects
Metabolic Diseases
/ prevention & control
Molecular Structure
Obesity
/ prevention & control
Protective Agents
/ chemistry
Signal Transduction
Structure-Activity Relationship
Tocotrienols
/ chemistry
adipose
diabetes
insulin resistance
metabolic syndrome
obesity
overweight
vitamin E
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Mar 2019
06 Mar 2019
Historique:
received:
28
12
2018
revised:
02
03
2019
accepted:
03
03
2019
entrez:
9
3
2019
pubmed:
9
3
2019
medline:
27
11
2019
Statut:
epublish
Résumé
Obesity is a major risk factor for diabetes, and these two metabolic conditions cause significant healthcare burden worldwide. Chronic inflammation and increased oxidative stress due to exposure of cells to excess nutrients in obesity may trigger insulin resistance and pancreatic β-cell dysfunction. Tocotrienol, as a functional food component with anti-inflammatory, antioxidant, and cell signaling-mediating effects, may be a potential agent to complement the current management of obesity and diabetes. The review aimed to summarize the current evidence on the anti-obesity and antidiabetic effects of tocotrienol. Previous studies showed that tocotrienol could suppress adipogenesis and, subsequently, reduce body weight and fat mass in animals. This was achieved by regulating pathways of lipid metabolism and fatty acid biosynthesis. It could also reduce the expression of transcription factors regulating adipogenesis and increase apoptosis of adipocytes. In diabetic models, tocotrienol was shown to improve glucose homeostasis. Activation of peroxisome proliferator-activated receptors was suggested to be responsible for these effects. Tocotrienol also prevented multiple systemic complications due to obesity and diabetes in animal models through suppression of inflammation and oxidative stress. Several clinical trials have been conducted to validate the antidiabetic of tocotrienol, but the results were heterogeneous. There is no evidence showing the anti-obesity effects of tocotrienol in humans. Considering the limitations of the current studies, tocotrienol has the potential to be a functional food component to aid in the management of patients with obesity and diabetes.
Identifiants
pubmed: 30845769
pii: molecules24050923
doi: 10.3390/molecules24050923
pmc: PMC6429133
pii:
doi:
Substances chimiques
Hypoglycemic Agents
0
Protective Agents
0
Tocotrienols
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Universiti Kebangsaan Malaysia
ID : GUP-2017-060
Organisme : Universiti Kebangsaan Malaysia
ID : FF-2018-405
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Physiol Rev. 1998 Jul;78(3):783-809
pubmed: 9674695
J Agric Food Chem. 2016 Jul 6;64(26):5361-6
pubmed: 27295311
Biochem Biophys Res Commun. 2004 Jul 2;319(3):1047-52
pubmed: 15184087
J Nutr Sci Vitaminol (Tokyo). 2007 Aug;53(4):301-5
pubmed: 17934234
Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):55-60
pubmed: 18598299
Front Pharmacol. 2016 Aug 30;7:291
pubmed: 27625609
Nutr J. 2013 Dec 27;12(1):166
pubmed: 24373555
Molecules. 2016 Mar 11;21(3):344
pubmed: 26978344
J Nutr Biochem. 2018 Jul;57:77-85
pubmed: 29679925
Mol Med Rep. 2012 Apr;5(4):905-9
pubmed: 22293775
Evid Based Complement Alternat Med. 2012;2012:747020
pubmed: 22919420
Int J Mol Sci. 2014 Dec 26;16(1):378-400
pubmed: 25548896
J Chem Biol. 2015 Jan 20;8(2):45-59
pubmed: 25870713
Nutr Res. 2010 Mar;30(3):209-16
pubmed: 20417882
World J Biol Chem. 2016 Feb 26;7(1):14-43
pubmed: 26981194
Free Radic Biol Med. 1991;10(5):263-75
pubmed: 1649783
Hepatology. 2010 Feb;51(2):679-89
pubmed: 20041406
Diabetologia. 2008 Jan;51(1):47-53
pubmed: 17994292
Front Cardiovasc Med. 2016 Oct 17;3:39
pubmed: 27800483
Lipids Health Dis. 2011 Feb 27;10:37
pubmed: 21352586
PLoS One. 2016 Apr 08;11(4):e0152562
pubmed: 27058737
J Nutr Sci Vitaminol (Tokyo). 2013;59(2):148-51
pubmed: 23727646
Int J Mol Sci. 2011;12(5):3117-32
pubmed: 21686173
Nutr Metab (Lond). 2014 Jan 13;11(1):5
pubmed: 24410975
Int J Food Sci Nutr. 2000;51 Suppl:S3-11
pubmed: 11271854
Nutr Rev. 2012 Sep;70(9):483-90
pubmed: 22946849
FEBS Lett. 1997 Jun 2;409(1):105-8
pubmed: 9199513
Clin Chem Lab Med. 2011 Nov;49(11):1773-82
pubmed: 21810068
Food Funct. 2015 Jul;6(7):2293-302
pubmed: 26073057
Toxicol Appl Pharmacol. 2013 Dec 1;273(2):314-24
pubmed: 24041758
Diabetes Res Clin Pract. 2011 May;92(2):253-60
pubmed: 21371770
J Biol Chem. 2007 Jan 5;282(1):809-20
pubmed: 17114179
Front Pharmacol. 2017 Jul 05;8:444
pubmed: 28725195
Diabetes Care. 2004 Feb;27(2):362-6
pubmed: 14747214
PLoS One. 2017 Mar 28;12(3):e0174542
pubmed: 28350848
J Nutr. 1996 Feb;126(2):389-94
pubmed: 8632210
Int J Prev Med. 2014 May;5(5):617-23
pubmed: 24932394
J Nutr. 2009 Jan;139(1):51-7
pubmed: 19056650
Life Sci. 2009 Feb 27;84(9-10):296-301
pubmed: 19162042
Mol Nutr Food Res. 2014 Mar;58(3):569-79
pubmed: 24668775
J Immunol. 2011 Jan 15;186(2):1173-9
pubmed: 21169551
Mol Vis. 2014 Jun 12;20:822-35
pubmed: 24940038
N Engl J Med. 2017 Jul 6;377(1):13-27
pubmed: 28604169
Int J Obes (Lond). 2015 Mar;39(3):438-46
pubmed: 25042861
N Engl J Med. 2017 Apr 13;376(15):1492
pubmed: 28402780
Biochemistry. 1993 Oct 12;32(40):10692-9
pubmed: 8399214
J Atheroscler Thromb. 2010 Oct 27;17(10):1019-32
pubmed: 20702976
Phytother Res. 2013 Feb;27(2):264-71
pubmed: 22566008
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20464-9
pubmed: 19074288
Biochim Biophys Acta. 2016 Apr;1862(4):647-650
pubmed: 26723540
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
Eur J Histochem. 2013 Aug 06;57(3):e24
pubmed: 24085273
Food Funct. 2014 Sep;5(9):2221-7
pubmed: 25055730
Nutr Res. 2016 Dec;36(12):1345-1352
pubmed: 27884413
Neuropharmacology. 2009 Sep;57(4):456-62
pubmed: 19555701
PPAR Res. 2007;2007:95974
pubmed: 17389767
Clin Exp Pharmacol Physiol. 2005 Sep;32(9):761-70
pubmed: 16173934
Biofactors. 2012 Nov-Dec;38(6):450-7
pubmed: 23047815
Lipids. 2012 May;47(5):471-81
pubmed: 22367056
Food Chem Toxicol. 2001 Aug;39(8):799-805
pubmed: 11434987
Eur J Clin Nutr. 2011 May;65(5):590-7
pubmed: 21245884
Atherosclerosis. 2016 Nov;254:205-214
pubmed: 27760402
J Med Food. 2004 Spring;7(1):45-51
pubmed: 15117552
Nutrition. 2014 Apr;30(4):466-72
pubmed: 24607304
Expert Opin Drug Saf. 2009 Sep;8(5):573-84
pubmed: 19538102
JAMA Neurol. 2018 Apr 1;75(4):444-452
pubmed: 29379943
J Nutr. 2009 May;139(5):884-9
pubmed: 19297424
Atherosclerosis. 2005 Oct;182(2):367-74
pubmed: 16159610
Clinics (Sao Paulo). 2009;64(3):235-44
pubmed: 19330251
J Obes Metab Syndr. 2017 Jun;26(2):102-106
pubmed: 31089503
Circ Res. 2010 Oct 29;107(9):1058-70
pubmed: 21030723
Eur J Nutr. 2017 Feb;56(1):133-150
pubmed: 26446095
Mol Nutr Food Res. 2010 Mar;54(3):345-52
pubmed: 19866471
Arch Med Sci. 2017 Jun;13(4):851-863
pubmed: 28721154
Science. 2003 Oct 17;302(5644):453-7
pubmed: 12970571
Mediators Inflamm. 2010;2010:453892
pubmed: 20182627
Sultan Qaboos Univ Med J. 2014 Feb;14(1):e95-e103
pubmed: 24516761
Saudi Pharm J. 2016 Sep;24(5):547-553
pubmed: 27752226
J Nutr. 2006 Jun;136(6):1472-6
pubmed: 16702306
Br J Pharmacol. 2009 Mar;156(5):713-27
pubmed: 19210748
Lipids. 2001 Jan;36(1):43-8
pubmed: 11214728
J Oleo Sci. 2017;66(2):171-179
pubmed: 28154348
Food Chem Toxicol. 2013 Sep;59:501-13
pubmed: 23816832
J Nutr Biochem. 2013 Jun;24(6):1146-52
pubmed: 23246159
Clin Chem. 2007 Mar;53(3):511-9
pubmed: 17272491
Phys Ther. 2008 Nov;88(11):1322-35
pubmed: 18801863
Lipids Health Dis. 2014 Dec 06;13:183
pubmed: 25481115
Nutrients. 2017 Feb 15;9(2):
pubmed: 28212283
Int J Mol Sci. 2016 Nov 18;17(11):
pubmed: 27869747
Clin Biochem. 2013 Jun;46(9):795-8
pubmed: 23473942
Nutrients. 2012 Oct 22;4(10):1527-41
pubmed: 23201770
Pharmacol Biochem Behav. 2009 Apr;92(2):251-9
pubmed: 19138703
Free Radic Biol Med. 2014 Mar;68:43-51
pubmed: 24296243
J Nutr Biochem. 2008 May;19(5):320-7
pubmed: 17683924
Fitoterapia. 2014 Jul;96:65-75
pubmed: 24731922
IUBMB Life. 2019 Apr;71(4):430-441
pubmed: 30681767
Diabetes. 2008 Jul;57(7):1952-65
pubmed: 18420487
Am J Clin Nutr. 2006 Oct;84(4):835-42
pubmed: 17023711
J Lipid Res. 2016 Jan;57(1):66-76
pubmed: 26628639
J Agric Food Chem. 2019 Jan 9;67(1):441-451
pubmed: 30562020
Arch Med Sci. 2010 Aug 30;6(4):505-12
pubmed: 22371792
J Nutr. 2002 Oct;132(10):3113-8
pubmed: 12368403
Oxid Med Cell Longev. 2017;2017:1930261
pubmed: 28845211
J Clin Biochem Nutr. 2009 Jul;45(1):29-36
pubmed: 19590704
J Hypertens. 2007 Jan;25(1):227-34
pubmed: 17143195
Chem Biol Interact. 2010 Dec 5;188(3):651-8
pubmed: 20816776
Malays J Pathol. 2002 Dec;24(2):77-82
pubmed: 12887164
Ann Med. 2010 Apr;42(3):178-86
pubmed: 20350251
J Nutr Sci Vitaminol (Tokyo). 2008 Aug;54(4):329-34
pubmed: 18797156
J Clin Endocrinol Metab. 2011 Jun;96(6):1654-63
pubmed: 21602457
J Nutr Biochem. 2017 Oct;48:128-137
pubmed: 28825992
Clin Ter. 2015;166(3):99-104
pubmed: 26152615
Evid Based Complement Alternat Med. 2011;2011:120801
pubmed: 21437191
J Biol Chem. 1993 May 25;268(15):11230-8
pubmed: 8388388
Diabetes Care. 2010 Aug;33(8):1865-71
pubmed: 20668155
Mol Cell Biochem. 1997 May;170(1-2):131-7
pubmed: 9144327
J Res Med Sci. 2015 Jun;20(6):540-7
pubmed: 26600828
Cell Death Dis. 2018 Jan 25;9(2):119
pubmed: 29371661
BMJ. 2016 Apr 06;353:i1575
pubmed: 27052837
Am J Med. 2003 Dec 8;115 Suppl 8A:42S-48S
pubmed: 14678865