Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system.
Berberine
Coptis japonica
Hydroponic cultivation
Journal
Journal of natural medicines
ISSN: 1861-0293
Titre abrégé: J Nat Med
Pays: Japan
ID NLM: 101518405
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
23
10
2018
accepted:
04
02
2019
pubmed:
9
3
2019
medline:
14
8
2019
entrez:
9
3
2019
Statut:
ppublish
Résumé
As a part of the investigation of the safety and efficacy of the cultivated Coptis japonica rhizome extracts using an artificial hydroponic cultivation system, the mutagenetic and anti-allergic activities were evaluated. Some extracts of commercial crude drugs of Coptis sp. were also evaluated for the comparison. None of the extracts showed a significant mutagenicity in Salmonella typhimurium TA102 by the Ames tests, but all the extracts showed in S. typhimurium TA98. The extracts of the hydroponically cultivated rhizomes showed anti-allergic activities against contact hypersensitivity as well as those of commercial crude drugs of Coptis sp. These results suggested the potential of the hydroponically cultivated rhizomes as one of the alternative sources for the medicinal usage.
Identifiants
pubmed: 30847756
doi: 10.1007/s11418-019-01288-6
pii: 10.1007/s11418-019-01288-6
doi:
Substances chimiques
Anti-Allergic Agents
0
Mutagens
0
Plant Extracts
0
Berberine
0I8Y3P32UF
Types de publication
Journal Article
Langues
eng
Pagination
608-613Références
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