Cystic Fibrosis Plasma Blunts the Immune Response to Bacterial Infection.
Bacterial Infections
/ immunology
Cells, Cultured
Cystic Fibrosis
/ genetics
Cystic Fibrosis Transmembrane Conductance Regulator
/ immunology
Humans
Leukocytes, Mononuclear
/ immunology
Lung
/ immunology
MicroRNAs
/ genetics
Monocytes
/ microbiology
Plasma
/ microbiology
Pseudomonas Infections
/ immunology
Pseudomonas aeruginosa
/ immunology
cystic fibrosis
gene expression
immune response
microRNA
peripheral blood mononuclear cells
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
pubmed:
9
3
2019
medline:
28
3
2020
entrez:
9
3
2019
Statut:
ppublish
Résumé
Cystic fibrosis (CF) is caused by mutations of the gene encoding the CF transmembrane conductance regulator. It remains unclear whether the abnormal immune response in CF involves extrinsic signals released from the external or internal environment. We sought to characterize the peripheral immune signatures in CF and its association with clinical phenotypes. Healthy peripheral blood mononuclear cells (PBMCs) were cultured with plasma from CF probands (CFPs) or healthy control subjects (HCs) followed by nCounter gene and microRNA (miRNA) profiling. A discovery cohort of 12 CFPs and 12 HCs and a validation cohort of 103 CFPs and 31 HCs (our previous microarray data [GSE71799]) were analyzed to characterize the composition of cultured immune cells and establish a miRNA‒mRNA network. Cell compositions and miRNA profiles were associated with clinical characteristics of the cohorts. Significantly differentially expressed genes and abundance of myeloid cells were downregulated in PMBCs after culture with CF plasma (
Identifiants
pubmed: 30848661
doi: 10.1165/rcmb.2018-0114OC
pmc: PMC6839930
doi:
Substances chimiques
CFTR protein, human
0
MicroRNAs
0
Cystic Fibrosis Transmembrane Conductance Regulator
126880-72-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-311Subventions
Organisme : NIH HHS
ID : DP2 OD007031
Pays : United States
Commentaires et corrections
Type : CommentIn
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