Eye and Behçet's disease.

Behcet Syndrome / complications Biological Products / therapeutic use Eye / drug effects Glucocorticoids / therapeutic use Humans Immunosuppressive Agents / therapeutic use Inflammation / complications Ocular Physiological Phenomena Retinal Vasculitis / drug therapy Uveitis / drug therapy Vision Disorders / drug therapy
Behçet's disease Biologics Blindness Corticosteroids Immunosuppressants Retinal vasculitis Uveitis

Journal

Journal francais d'ophtalmologie
ISSN: 1773-0597
Titre abrégé: J Fr Ophtalmol
Pays: France
ID NLM: 7804128

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 19 12 2018
revised: 25 12 2018
accepted: 07 02 2019
pubmed: 10 3 2019
medline: 23 8 2019
entrez: 10 3 2019
Statut: ppublish

Résumé

Behçet's disease is a chronic multisystem disorder characterized by relapsing inflammation for which the underlying histopathology is an occlusive vasculitis. The disease has a high prevalence in the Mediterranean region, Far and Middle Eastern countries. It is clinically characterized by oral and genital ulcerations, ocular inflammatory involvement, skin lesions, vascular involvement and numerous other systemic manifestations. Uveitis is by far the most common ocular manifestation of Behçet's disease. It typically presents in the form of relapsing-remitting panuveitis with retinal vasculitis that may result in severe visual loss. Management of Behçet's uveitis relies on corticosteroid therapy, conventional immunosuppressive drugs and biological agents and requires a close collaboration between ophthalmologist and internist. A better understanding of auto-inflammatory process and of the role of cytokines implicated in the pathogenesis of Behçet's disease will enable researchers to develop more specific and effective therapy.

Identifiants

DOI: 10.1016/j.jfo.2019.02.002 PMID: 30850197
pubmed: 30850197
pii: S0181-5512(19)30068-3
doi: 10.1016/j.jfo.2019.02.002
pii:
doi:

Substances chimiques

Biological Products 0
Glucocorticoids 0
Immunosuppressive Agents 0

Types de publication

Journal Article Review

Langues

eng

Pagination

e133-e146

Informations de copyright

Copyright © 2019 Elsevier Masson SAS. All rights reserved.

Auteurs

I Ksiaa (I)

Service d'ophtalmologie, hôpital universitaire Fattouma Bourguiba, faculté de médecine, université de Monastir, 5019 Monastir, Tunisie.

N Abroug (N)

Service d'ophtalmologie, hôpital universitaire Fattouma Bourguiba, faculté de médecine, université de Monastir, 5019 Monastir, Tunisie.

M Kechida (M)

Service de médecine interne, hôpital universitaire Fattouma Bourguiba, faculté de médecine, université de Monastir, Monastir, Tunisie.

S Zina (S)

Service d'ophtalmologie, hôpital universitaire Fattouma Bourguiba, faculté de médecine, université de Monastir, 5019 Monastir, Tunisie.

B Jelliti (B)

Service d'ophtalmologie, hôpital universitaire Fattouma Bourguiba, faculté de médecine, université de Monastir, 5019 Monastir, Tunisie.

S Khochtali (S)

Service d'ophtalmologie, hôpital universitaire Fattouma Bourguiba, faculté de médecine, université de Monastir, 5019 Monastir, Tunisie.

S Attia (S)

Service d'ophtalmologie, hôpital universitaire Fattouma Bourguiba, faculté de médecine, université de Monastir, 5019 Monastir, Tunisie.

M Khairallah (M)

Service d'ophtalmologie, hôpital universitaire Fattouma Bourguiba, faculté de médecine, université de Monastir, 5019 Monastir, Tunisie. Electronic address: moncef.khairallah@yahoo.fr.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses vasculaires › Maladie de Behçet › Eye and Behçet's disease.
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Eye and Behçet's disease.
questionsmedicales.fr › Organes des sens › Oeil › Eye and Behçet's disease.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Glucocorticoïdes › Eye and Behçet's disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Eye and Behçet's disease.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Eye and Behçet's disease.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Eye and Behçet's disease.
questionsmedicales.fr › Phénomènes physiologiques oculaires › Eye and Behçet's disease.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Vascularite › Vascularite rétinienne › Eye and Behçet's disease.
questionsmedicales.fr › Maladies de l'oeil › Maladies de l'uvée › Uvéite › Eye and Behçet's disease.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de la vision › Eye and Behçet's disease.