Inflammatory parameters associated with systemic reactogenicity following vaccination with adjuvanted hepatitis B vaccines in humans.
Association with systemic symptoms
HBsAg-AS01B adjuvanted vaccine
IFNγ signals
IL-6 signals
Innate response
Reactogenicity
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
28 03 2019
28 03 2019
Historique:
received:
12
09
2018
revised:
14
12
2018
accepted:
05
02
2019
pubmed:
10
3
2019
medline:
8
8
2020
entrez:
10
3
2019
Statut:
ppublish
Résumé
Adjuvants like AS01 The trial involved 60 hepatitis B-naïve adults aged 18-45 years randomized 1:1 to receive either two doses of HBsAg-AS01 The vaccine with AS01 IL-6 and IFN-γ signals were associated with systemic reactogenicity following administration of AS01 www.clinicaltrials.gov NCT01777295.
Sections du résumé
BACKGROUND
Adjuvants like AS01
METHODS
The trial involved 60 hepatitis B-naïve adults aged 18-45 years randomized 1:1 to receive either two doses of HBsAg-AS01
FINDINGS
The vaccine with AS01
CONCLUSIONS
IL-6 and IFN-γ signals were associated with systemic reactogenicity following administration of AS01
TRIAL REGISTRATION
www.clinicaltrials.gov NCT01777295.
Identifiants
pubmed: 30850240
pii: S0264-410X(19)30209-9
doi: 10.1016/j.vaccine.2019.02.015
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Hepatitis B Antibodies
0
Hepatitis B Vaccines
0
Inflammation Mediators
0
Banques de données
ClinicalTrials.gov
['NCT01777295', 'NCT00805389']
Types de publication
Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2004-2015Informations de copyright
Copyright © 2019 GlaxoSmithKline Biologicals SA. Published by Elsevier Ltd.. All rights reserved.