Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models.
Animals
Brain
/ embryology
Catechin
/ administration & dosage
Cognition
Disease Models, Animal
Down Syndrome
/ diet therapy
Female
Glutamate Decarboxylase
/ physiology
Interneurons
/ pathology
Maternal-Fetal Exchange
Maze Learning
Mice
Mice, Inbred C57BL
Mice, Transgenic
Pregnancy
Protein Serine-Threonine Kinases
/ antagonists & inhibitors
Protein-Tyrosine Kinases
/ antagonists & inhibitors
Tea
Dyrk Kinases
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 03 2019
08 03 2019
Historique:
received:
12
03
2018
accepted:
31
01
2019
entrez:
10
3
2019
pubmed:
10
3
2019
medline:
30
9
2020
Statut:
epublish
Résumé
Down syndrome is a common genetic disorder caused by trisomy of chromosome 21. Brain development in affected foetuses might be improved through prenatal treatment. One potential target is DYRK1A, a multifunctional kinase encoded by chromosome 21 that, when overexpressed, alters neuronal excitation-inhibition balance and increases GAD67 interneuron density. We used a green tea extract enriched in EGCG to inhibit DYRK1A function only during gestation of transgenic mice overexpressing Dyrk1a (mBACtgDyrk1a). Adult mice treated prenatally displayed reduced levels of inhibitory markers, restored VGAT1/VGLUT1 balance, and rescued density of GAD67 interneurons. Similar results for gabaergic and glutamatergic markers and interneuron density were obtained in Dp(16)1Yey mice, trisomic for 140 chromosome 21 orthologs; thus, prenatal EGCG exhibits efficacy in a more complex DS model. Finally, cognitive and behaviour testing showed that adult Dp(16)1Yey mice treated prenatally had improved novel object recognition memory but do not show improvement with Y maze paradigm. These findings provide empirical support for a prenatal intervention that targets specific neural circuitries.
Identifiants
pubmed: 30850713
doi: 10.1038/s41598-019-40328-9
pii: 10.1038/s41598-019-40328-9
pmc: PMC6408590
doi:
Substances chimiques
Tea
0
Catechin
8R1V1STN48
epigallocatechin gallate
BQM438CTEL
Protein-Tyrosine Kinases
EC 2.7.10.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Glutamate Decarboxylase
EC 4.1.1.15
glutamate decarboxylase 1
EC 4.1.1.15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3914Références
Neurosci Lett. 2005 Jul 15;382(3):317-22
pubmed: 15925111
EBioMedicine. 2015 Jan 17;2(2):120-34
pubmed: 26137553
Neuroscience. 2016 Oct 1;333:277-301
pubmed: 27457036
Anal Biochem. 2014 Mar 15;449:172-8
pubmed: 24374000
Physiol Behav. 2017 Aug 1;177:230-241
pubmed: 28478033
J Neurosci. 1999 Sep 15;19(18):7881-8
pubmed: 10479690
PLoS One. 2009;4(2):e4606
pubmed: 19242551
J Neural Transm (Vienna). 2010 Apr;117(4):445-55
pubmed: 20157742
Neurosci Lett. 1990 May 18;113(1):17-22
pubmed: 2142259
PLoS One. 2014 Sep 04;9(9):e106572
pubmed: 25188425
Neurobiol Dis. 2012 Apr;46(1):190-203
pubmed: 22293606
Lancet Neurol. 2016 Jul;15(8):801-810
pubmed: 27302362
J Neurosci. 2012 Apr 4;32(14):4755-61
pubmed: 22492031
Biochem J. 2003 Apr 1;371(Pt 1):199-204
pubmed: 12534346
Sci Rep. 2017 Apr 4;7(1):619
pubmed: 28377597
Carcinogenesis. 1998 Oct;19(10):1771-6
pubmed: 9806157
J Neurosci. 2008 Apr 2;28(14):3623-30
pubmed: 18385321
Neurobiol Dis. 2017 Oct;106:76-88
pubmed: 28647555
Neurobiol Dis. 2018 Jul;115:1-8
pubmed: 29550538
J Neurosci. 2004 Sep 15;24(37):8153-60
pubmed: 15371516
Br J Pharmacol. 2013 Jul;169(5):963-73
pubmed: 23489250
Neurobiol Dis. 2014 Mar;63:12-9
pubmed: 24269730
Mol Brain. 2013 Jul 19;6:33
pubmed: 23870245
Brain Res Brain Res Protoc. 2001 Jul;7(3):211-21
pubmed: 11431122
Nat Protoc. 2006;1(3):1306-11
pubmed: 17406415
Hum Mol Genet. 2016 Nov 15;25(22):4856-4869
pubmed: 28172997
Hum Reprod. 2007 Jan;22(1):280-7
pubmed: 16959805
Elife. 2018 Feb 27;7:
pubmed: 29485402
Trends Neurosci. 2005 Jun;28(6):278-83
pubmed: 15927682
Science. 1997 Oct 17;278(5337):474-6
pubmed: 9334308
Neurochem Res. 2015 Jan;40(1):151-64
pubmed: 25399236
Neurobiol Dis. 2014 Sep;69:65-75
pubmed: 24801365
Curr Opin Obstet Gynecol. 2014 Apr;26(2):92-103
pubmed: 24573065
Nat Neurosci. 2002 Dec;5(12):1279-87
pubmed: 12411960
Trends Mol Med. 2015 Apr;21(4):256-68
pubmed: 25824541
Biochemistry. 2006 Oct 3;45(39):12011-9
pubmed: 17002300
Sci Rep. 2017 Dec 4;7(1):16825
pubmed: 29203796
J Neurosci. 2013 Feb 27;33(9):3953-66
pubmed: 23447605
Brain Pathol. 2018 Nov;28(6):986-998
pubmed: 29509279
J Physiol. 2007 Feb 15;579(Pt 1):53-67
pubmed: 17158177
J Neurosci. 2014 Jan 22;34(4):1138-47
pubmed: 24453307
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Mar 2;82:187-194
pubmed: 29169997
Exp Neurol. 2012 Feb;233(2):749-57
pubmed: 22178330
J Neurosci Res. 2012 May;90(5):999-1010
pubmed: 22252917
J Neurosci. 2012 Jul 4;32(27):9217-27
pubmed: 22764230
Nat Neurosci. 2007 Apr;10(4):411-3
pubmed: 17322876
Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10268-10273
pubmed: 28874550
J Agric Food Chem. 2007 Feb 21;55(4):1517-24
pubmed: 17256961
Neurobiol Learn Mem. 2004 Jul;82(1):26-34
pubmed: 15183168
Neurology. 1984 Jul;34(7):909-16
pubmed: 6234479
J Neurosci. 2016 Mar 9;36(10):2926-44
pubmed: 26961948
J Med Genet. 2012 Dec;49(12):731-6
pubmed: 23099646
J Neurosci. 2000 Dec 1;20(23):8853-60
pubmed: 11102494
Sci Rep. 2016 Sep 02;6:32353
pubmed: 27586445
Free Radic Biol Med. 2018 Jan;114:33-39
pubmed: 28993272
Physiol Rep. 2015 Dec;3(12):
pubmed: 26702072
Dev Psychobiol. 2009 Dec;51(8):672-8
pubmed: 19739136
Nat Med. 2015 Apr;21(4):318-26
pubmed: 25774849
Biol Chem. 2002 Jan;383(1):101-5
pubmed: 11928805
Hum Mol Genet. 2015 Nov 15;24(22):6540-51
pubmed: 26374847
Mol Nutr Food Res. 2014 Feb;58(2):278-88
pubmed: 24039182
Front Behav Neurosci. 2015 Oct 20;9:267
pubmed: 26539088
Nat Neurosci. 2010 Aug;13(8):927-34
pubmed: 20639873