Vitamin D metabolism in dogs with and without hypercalciuric calcium oxalate urolithiasis.
calcitriol
canine
hypercalciuria
stones
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
24
07
2018
accepted:
23
01
2019
pubmed:
10
3
2019
medline:
11
5
2019
entrez:
10
3
2019
Statut:
ppublish
Résumé
There are abnormalities in vitamin D metabolism in people with calcium nephrolithiasis, but limited data are available on vitamin D status in dogs with calcium oxalate (CaOx) urolithiasis. To compare serum concentrations of vitamin D metabolites in dogs with and without hypercalciuric CaOx urolithiasis. Thirty-eight dogs with (n = 19) and without (n = 19) a history of CaOx urolithiasis and hypercalciuria. Retrospective cross-sectional study. Serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH) There were no significant differences between cases and controls when comparing 25(OH)D, 24,25(OH) These data suggest that decreased conversion of 25(OH)D to 24,25(OH)
Sections du résumé
BACKGROUND
BACKGROUND
There are abnormalities in vitamin D metabolism in people with calcium nephrolithiasis, but limited data are available on vitamin D status in dogs with calcium oxalate (CaOx) urolithiasis.
OBJECTIVE
OBJECTIVE
To compare serum concentrations of vitamin D metabolites in dogs with and without hypercalciuric CaOx urolithiasis.
ANIMALS
METHODS
Thirty-eight dogs with (n = 19) and without (n = 19) a history of CaOx urolithiasis and hypercalciuria.
METHODS
METHODS
Retrospective cross-sectional study. Serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)
RESULTS
RESULTS
There were no significant differences between cases and controls when comparing 25(OH)D, 24,25(OH)
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
These data suggest that decreased conversion of 25(OH)D to 24,25(OH)
Identifiants
pubmed: 30851134
doi: 10.1111/jvim.15442
pmc: PMC6430952
doi:
Substances chimiques
Vitamin D
1406-16-2
Calcium Oxalate
2612HC57YE
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
758-763Subventions
Organisme : NIH HHS
ID : K01 OD019912
Pays : United States
Organisme : National Institute of Health
ID : 1K01OD019912-03
Organisme : University of Minnesota
ID : Small Companion Animal Research Grant
Informations de copyright
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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