Genetics of Alcoholism.
Alcohol dehydrogenase
Alcohol dependence
Alcoholism
Drinking
GWAS
Genetics
Journal
Current psychiatry reports
ISSN: 1535-1645
Titre abrégé: Curr Psychiatry Rep
Pays: United States
ID NLM: 100888960
Informations de publication
Date de publication:
09 03 2019
09 03 2019
Historique:
entrez:
11
3
2019
pubmed:
11
3
2019
medline:
6
2
2020
Statut:
epublish
Résumé
We review the search for genetic variants that affect the risk for alcohol dependence and alcohol consumption. Variations in genes affecting alcohol metabolism (ADH1B, ALDH2) are protective against both alcohol dependence and excessive consumption, but different variants are found in different populations. There are different patterns of risk variants for alcohol dependence vs. consumption. Variants for alcohol dependence, but not consumption, are associated with risk for other psychiatric illnesses. ADH1B and ALDH2 strongly affect both consumption and dependence. Variations in many other genes affect both consumption and dependence-or one or the other of these traits-but individual effect sizes are small. Evidence for other specific genes that affect dependence is not yet strong. Most current knowledge derives from studies of European-ancestry populations, and large studies of carefully phenotyped subjects from different populations are needed to understand the genetic contributions to alcohol consumption and alcohol use disorders.
Identifiants
pubmed: 30852706
doi: 10.1007/s11920-019-1008-1
pii: 10.1007/s11920-019-1008-1
doi:
Substances chimiques
ADH1B protein, human
EC 1.1.1.1
Alcohol Dehydrogenase
EC 1.1.1.1
ALDH2 protein, human
EC 1.2.1.3
Aldehyde Dehydrogenase, Mitochondrial
EC 1.2.1.3
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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