Maternal exposure to imazalil disrupts the endocrine system in F
Androgens
/ blood
Animals
Aromatase
/ metabolism
Crosses, Genetic
Endocrine Disruptors
/ toxicity
Endocrine System
/ drug effects
Estrogens
/ blood
Female
Imidazoles
/ chemistry
Lipids
/ blood
Male
Maternal Exposure
Mice, Inbred C57BL
Molecular Docking Simulation
Ovary
/ drug effects
Pregnancy
Prenatal Exposure Delayed Effects
/ pathology
Receptors, Androgen
/ genetics
Receptors, Estrogen
/ genetics
Testis
/ drug effects
Transcription, Genetic
/ drug effects
Uterus
/ drug effects
AR antagonist
Aromatase deficiency
Imazalil
Mice
Transgenerational endocrine disruption
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
28
11
2018
revised:
01
03
2019
accepted:
04
03
2019
pubmed:
12
3
2019
medline:
18
1
2020
entrez:
12
3
2019
Statut:
ppublish
Résumé
The fungicide imazalil (IMZ), an AR antagonist, has been linked to endocrine disruption in animals. Here, adult female C57BL/6 mice were administered IMZ through their drinking water at levels of 0, 0.025‰ and 0.25‰ during the gestation and lactation periods (the exposed females are marked as F
Identifiants
pubmed: 30853599
pii: S0303-7207(19)30078-4
doi: 10.1016/j.mce.2019.03.002
pii:
doi:
Substances chimiques
Androgens
0
Endocrine Disruptors
0
Estrogens
0
Imidazoles
0
Lipids
0
Receptors, Androgen
0
Receptors, Estrogen
0
enilconazole
6K0NOF3XQ6
Aromatase
EC 1.14.14.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105-112Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.