Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype.
Animals
Antioxidants
/ therapeutic use
DNA Methylation
/ drug effects
Female
Fetal Growth Retardation
/ drug therapy
Fetus
/ drug effects
Gene Expression
/ drug effects
Male
Oxidative Stress
/ drug effects
Phenotype
Phenylethyl Alcohol
/ analogs & derivatives
Placenta
/ drug effects
Polyphenols
/ therapeutic use
Pregnancy
Swine
antioxidants
intrauterine-growth-restriction
pregnancy
swine-model
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Mar 2019
08 Mar 2019
Historique:
received:
07
02
2019
revised:
27
02
2019
accepted:
05
03
2019
entrez:
13
3
2019
pubmed:
13
3
2019
medline:
25
6
2019
Statut:
epublish
Résumé
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found.
Identifiants
pubmed: 30857182
pii: ijms20051187
doi: 10.3390/ijms20051187
pmc: PMC6429121
pii:
doi:
Substances chimiques
Antioxidants
0
Polyphenols
0
3,4-dihydroxyphenylethanol
10597-60-1
Phenylethyl Alcohol
ML9LGA7468
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : project AGL2013-48121-C3-R and AGL2016-79321-C2-2-R
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