Inflammatory macrophage dependence on NAD
Acrylamides
/ pharmacology
Animals
Cells, Cultured
Cytokines
/ metabolism
DNA Damage
Electron Transport Complex III
/ metabolism
HEK293 Cells
Humans
Inflammation
/ metabolism
Macrophage Activation
Macrophages
/ drug effects
Mice
Mice, Inbred C57BL
Mitochondria
/ metabolism
NAD
/ metabolism
Nicotinamide Phosphoribosyltransferase
/ metabolism
Piperidines
/ pharmacology
Reactive Oxygen Species
/ metabolism
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
21
05
2018
accepted:
25
01
2019
pubmed:
13
3
2019
medline:
20
4
2019
entrez:
13
3
2019
Statut:
ppublish
Résumé
The adoption of Warburg metabolism is critical for the activation of macrophages in response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase their expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in NAD
Identifiants
pubmed: 30858618
doi: 10.1038/s41590-019-0336-y
pii: 10.1038/s41590-019-0336-y
doi:
Substances chimiques
Acrylamides
0
Cytokines
0
N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide
0
Piperidines
0
Reactive Oxygen Species
0
NAD
0U46U6E8UK
Nicotinamide Phosphoribosyltransferase
EC 2.4.2.12
nicotinamide phosphoribosyltransferase, mouse
EC 2.4.2.12
Electron Transport Complex III
EC 7.1.1.8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
420-432Subventions
Organisme : Wellcome Trust
ID : 201330/Z/16/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI053825
Pays : United States
Commentaires et corrections
Type : CommentIn