Variation in ribosomal DNA copy number is associated with lung cancer risk in a prospective cohort study.
Aged
Carcinogenesis
/ genetics
Case-Control Studies
Cohort Studies
DNA Copy Number Variations
/ genetics
DNA, Ribosomal
/ blood
Dietary Supplements
Finland
/ epidemiology
Humans
Lung Neoplasms
/ blood
Male
Middle Aged
Risk Factors
Smoking
/ adverse effects
alpha-Tocopherol
/ administration & dosage
beta Carotene
/ administration & dosage
Journal
Carcinogenesis
ISSN: 1460-2180
Titre abrégé: Carcinogenesis
Pays: England
ID NLM: 8008055
Informations de publication
Date de publication:
22 08 2019
22 08 2019
Historique:
received:
19
12
2018
revised:
07
02
2019
accepted:
08
03
2019
pubmed:
13
3
2019
medline:
10
5
2020
entrez:
13
3
2019
Statut:
ppublish
Résumé
Disruption of ribosomal DNA (rDNA) has been linked to a variety of diseases in humans, including carcinogenesis. To evaluate the associations between rDNA copy number (CN) and risk of lung cancer, we measured 5.8S and 18S rDNA CN in the peripheral blood of 229 incident lung cancer cases and 1:1 matched controls from a nested case-control study within a prospective cohort of male smokers. There was a dose-response relationship between quartiles of both 18S and 5.8S rDNA CN and risk of lung cancer (odds ratio [OR], 95% confidence interval [CI]: 18S: 1.0 [ref]; 1.2 [0.6-2.1]; 1.8 [1.0-3.4]; 2.3 [1.3-4.1; Ptrend = 0.0002; 5.8S: 1.0 [ref]; 1.6 [0.8-2.9]; 2.2 [1.1-4.2]; 2.6 [1.3-5.1]; Ptrend = 0.0001). The associations between rDNA CN and lung cancer risk were similar when excluding cases diagnosed within 5 years of follow-up, and when stratifying by heavy (>20 cigarettes per day) and light smokers (≤20 cigarettes per day). We are the first to report that rDNA CN may be associated with future risk of lung cancer. To further elucidate the relationship between rDNA and lung cancer, replication studies are needed in additional populations, particularly those that include non-smokers.
Identifiants
pubmed: 30859204
pii: 5374822
doi: 10.1093/carcin/bgz052
pmc: PMC6736087
doi:
Substances chimiques
DNA, Ribosomal
0
beta Carotene
01YAE03M7J
alpha-Tocopherol
H4N855PNZ1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
975-978Subventions
Organisme : NIA NIH HHS
ID : R01 AG038797
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201500005C
Pays : United States
Informations de copyright
Published by Oxford University Press 2019.
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