Expression of Cripto-1 in the placenta and its role in placenta accreta and placenta previa.
Cripto-1
pathogenesis
placenta increta
placenta previa
pregnancy
Journal
Ginekologia polska
ISSN: 2543-6767
Titre abrégé: Ginekol Pol
Pays: Poland
ID NLM: 0374641
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
10
2018
accepted:
20
01
2019
revised:
18
01
2019
entrez:
13
3
2019
pubmed:
13
3
2019
medline:
10
1
2020
Statut:
ppublish
Résumé
This study Aims to explore the role of placental Cripto-1 in the incidence of an adherent placenta. Ten pregnant women with placenta increta, 20 pregnant women with placenta previa and 30 women with normal pregnant were enrolled in this study. Reverse transcription-polymerase chain reaction (RT-PCR) was used to measure the expression of Cripto-1 in the placenta while as the analysis of placental Cripto-1 was performed by Western blotting RESULTS: The placenta increta group showed higher levels of Cripto-1 in the center of the increta as compared to the non-implantation area. The level of placental Cripto-1 in the placenta increta was higher than that of the placenta accrete. The expression of placental Cripto-1 in the placenta increta and placenta previa groups was higher than that of control. Placental Cripto-1 is involved in the regulation of placental tissue invasion. Additionally, excessive placental growth or penetration into the myometrium are likely to be involved in the development of placenta increta.
Identifiants
pubmed: 30860275
pii: VM/OJS/J/60541
doi: 10.5603/GP.2019.0015
doi:
Substances chimiques
GPI-Linked Proteins
0
Intercellular Signaling Peptides and Proteins
0
Neoplasm Proteins
0
TDGF1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM