Protein intake is not associated with progression of diabetic kidney disease in patients without macroalbuminuria.
Aged
Albuminuria
/ complications
Diabetes Mellitus, Type 2
/ complications
Diabetic Nephropathies
/ epidemiology
Dietary Proteins
/ administration & dosage
Disease Progression
Eating
/ physiology
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Kidney
/ pathology
Male
Middle Aged
Retrospective Studies
estimated glomerular filtration rate
protein intake
type 2 diabetes
urinary albumin excretion
Journal
Diabetes/metabolism research and reviews
ISSN: 1520-7560
Titre abrégé: Diabetes Metab Res Rev
Pays: England
ID NLM: 100883450
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
13
09
2018
revised:
10
01
2019
accepted:
05
03
2019
pubmed:
13
3
2019
medline:
8
2
2020
entrez:
13
3
2019
Statut:
ppublish
Résumé
Diabetic kidney disease is an important problem in individuals with diabetes. The effect of dietary protein intake on the renal function of patients with diabetes is controversial. Here, we sought to clarify the association between dietary protein intake and changes in the urinary albumin excretion (UAE) or estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes. In this retrospective cohort study, we included 144 patients (70 men, mean ± standard deviation of age 64 ± 10 years, and median (interquartile range) of UAE 15.0 (7.0-38.9) mg/gCr) without an eGFR less than 30 mL/min/1.73 m The median follow-up duration was 5 years. Protein intake (g/kg ideal body weight/day) was not associated with the change in the UAE (r = -0.130, p = 0.120) or change in the eGFR (r = -0.074, p = 0.381). Multiple linear regression analyses showed that after adjusting for covariates, the patients' protein intake was not associated with change in their UAE (standardized regression coefficient: 0.044, p = 0.732) or change in their eGFR (standardized regression coefficient: 0.250, p = 0.085). Dietary protein intake does not influence changes in the UAE or eGFR among patients with type 2 diabetes without macroalbuminuria.
Sections du résumé
BACKGROUND
Diabetic kidney disease is an important problem in individuals with diabetes. The effect of dietary protein intake on the renal function of patients with diabetes is controversial. Here, we sought to clarify the association between dietary protein intake and changes in the urinary albumin excretion (UAE) or estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.
METHODS
In this retrospective cohort study, we included 144 patients (70 men, mean ± standard deviation of age 64 ± 10 years, and median (interquartile range) of UAE 15.0 (7.0-38.9) mg/gCr) without an eGFR less than 30 mL/min/1.73 m
RESULTS
The median follow-up duration was 5 years. Protein intake (g/kg ideal body weight/day) was not associated with the change in the UAE (r = -0.130, p = 0.120) or change in the eGFR (r = -0.074, p = 0.381). Multiple linear regression analyses showed that after adjusting for covariates, the patients' protein intake was not associated with change in their UAE (standardized regression coefficient: 0.044, p = 0.732) or change in their eGFR (standardized regression coefficient: 0.250, p = 0.085).
CONCLUSIONS
Dietary protein intake does not influence changes in the UAE or eGFR among patients with type 2 diabetes without macroalbuminuria.
Substances chimiques
Dietary Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3150Informations de copyright
© 2019 John Wiley & Sons, Ltd.