Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II.
bipolar disorder
cortical thickness
cortical thinning
depressive episodes
longitudinal study
progressive changes
Journal
Bipolar disorders
ISSN: 1399-5618
Titre abrégé: Bipolar Disord
Pays: Denmark
ID NLM: 100883596
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
pubmed:
14
3
2019
medline:
16
1
2020
entrez:
14
3
2019
Statut:
ppublish
Résumé
Previous studies found evidence for thinner frontotemporal cortices in bipolar disorder (BD), yet whether this represents a stable disease trait or an effect of mood episodes remains unknown. Here, we assessed the reproducibility of thinner frontotemporal cortices in BD type II, compared longitudinal changes in cortical thickness between individuals with BD type II and healthy controls (HCs), and examined the effect of mood episodes on cortical thickness change. Thirty-three HCs and 29 individuals with BD type II underwent 3T magnetic resonance imaging at baseline, as published previously, and 2.4 years later, at follow-up. Cross-sectional and longitudinal analyses of cortical thickness were performed using Freesurfer, and relationships with mood episodes from baseline to follow-up were assessed. Individuals with BD type II had thinner left and right prefrontal and left temporal cortex clusters at follow-up (all corrected P < 0.001), consistent with baseline results. Both groups showed widespread longitudinal cortical thinning, and patients had increased thinning in a left temporal cortex cluster compared to HCs (corrected P < 0.001). Patients with more (>2) depressive episodes between baseline and follow-up had greater left temporal cortical thinning than patients with fewer depressive episodes (corrected P < 0.05). In addition, patients with more depressive episodes had greater thinning in bilateral ventromedial prefrontal clusters relative to HCs (uncorrected P < 0.05), yet these results did not survive correction for multiple comparisons. Together, these findings support reduced frontotemporal cortical thickness in BD type II and provide the first preliminary evidence for an association between depressive episodes and increased cortical thinning.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
525-538Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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