A common genomic code for chromatin architecture and recombination landscape.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
08
2018
accepted:
18
02
2019
entrez:
14
3
2019
pubmed:
14
3
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Recent findings established a link between DNA sequence composition and interphase chromatin architecture and explained the evolutionary conservation of TADs (Topologically Associated Domains) and LADs (Lamina Associated Domains) in mammals. This prompted us to analyse conformation capture and recombination rate data to study the relationship between chromatin architecture and recombination landscape of human and mouse genomes. The results reveal that: (1) low recombination domains and blocks of elevated linkage disequilibrium tend to coincide with TADs and isochores, indicating co-evolving regulatory elements and genes in insulated neighbourhoods; (2) double strand break (DSB) and recombination frequencies increase in the short loops of GC-rich TADs, whereas recombination cold spots are typical of LADs and (3) the binding and loading of proteins, which are critical for DSB and meiotic recombination (SPO11, DMC1, H3K4me3 and PRMD9) are higher in GC-rich TADs. One explanation for these observations is that the occurrence of DSB and recombination in meiotic cells are associated with compositional and epigenetic features (genomic code) that influence DNA stiffness/flexibility and appear to be similar to those guiding the chromatin architecture in the interphase nucleus of pre-leptotene cells.
Identifiants
pubmed: 30865674
doi: 10.1371/journal.pone.0213278
pii: PONE-D-18-25400
pmc: PMC6415826
doi:
Substances chimiques
Chromatin
0
Histones
0
Isochores
0
histone H3 trimethyl Lys4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0213278Subventions
Organisme : NIH HHS
ID : S10 OD018164
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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