The effects of binary mixtures of estradiol and progesterone on transcriptional expression profiles of genes involved in hypothalamic-pituitary-gonadal axis and circadian rhythm signaling in embryonic zebrafish (Danio rerio).
Circadian rhythm signaling
Estradiol
Hypothalamic-pituitary-gonadal axis
Mixture effects
Progesterone
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
15 Jun 2019
15 Jun 2019
Historique:
received:
28
12
2018
revised:
27
02
2019
accepted:
05
03
2019
pubmed:
14
3
2019
medline:
23
4
2019
entrez:
14
3
2019
Statut:
ppublish
Résumé
Natural and synthetic estrogens and progestins are present in the various aquatic environments, leading to potential exposure of aquatic organisms to their mixtures. However, very little is known about their combined effects in aquatic organisms. The aim of this study was to analyze the effects of binary mixtures of estradiol (E2) and progesterone (P4) by measuring transcriptional changes of up to 42 selected target genes related to hypothalamic-pituitary-gonadal axis and circadian rhythm signaling in zebrafish (Danio rerio) eleuthero-embryos. Zebrafish embryos were exposed to E2 and P4 alone or in combination at concentrations between 45 and 5217 ng L
Identifiants
pubmed: 30865910
pii: S0147-6513(19)30282-9
doi: 10.1016/j.ecoenv.2019.03.021
pii:
doi:
Substances chimiques
Water Pollutants, Chemical
0
Progesterone
4G7DS2Q64Y
Estradiol
4TI98Z838E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
540-548Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.