Co-opting oxylipin signals in microbial disease.


Journal

Cellular microbiology
ISSN: 1462-5822
Titre abrégé: Cell Microbiol
Pays: India
ID NLM: 100883691

Informations de publication

Date de publication:
06 2019
Historique:
received: 19 11 2018
revised: 01 02 2019
accepted: 06 02 2019
pubmed: 14 3 2019
medline: 12 8 2020
entrez: 14 3 2019
Statut: ppublish

Résumé

Oxylipins, or oxygenated lipids, are universal signalling molecules across all kingdoms of life. These molecules, either produced by microbial pathogens or their mammalian host, regulate inflammation during microbial infection. In this review, we summarise current literature on the biosynthesis pathways of microbial oxylipins and their biological activity towards mammalian cells. Collectively, these studies have illustrated how microbial pathogens can modulate immune rsponse and disease outcome via oxylipin-mediated mechanisms.

Identifiants

pubmed: 30866138
doi: 10.1111/cmi.13025
pmc: PMC6538080
mid: NIHMS1523794
doi:

Substances chimiques

Eicosanoids 0
Oxylipins 0
Lipoxygenases EC 1.13.11.-
Prostaglandin-Endoperoxide Synthases EC 1.14.99.1
Phospholipases EC 3.1.-
Epoxide Hydrolases EC 3.3.2.-
Thromboxane-A Synthase EC 5.3.99.5

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e13025

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI065728
Pays : United States

Informations de copyright

© 2019 John Wiley & Sons Ltd.

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Auteurs

Mengyao Niu (M)

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin.

Nancy P Keller (NP)

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin.
Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin.

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Classifications MeSH