Functional and effective reorganization of the aging brain during unimanual and bimanual hand movements.
aging
granger causality
magnetoencephalography
motor control
network connectivity
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
23
09
2018
revised:
20
02
2019
accepted:
04
03
2019
pubmed:
14
3
2019
medline:
31
3
2020
entrez:
14
3
2019
Statut:
ppublish
Résumé
Motor performance decline observed during aging is linked to changes in brain structure and function, however, the precise neural reorganization associated with these changes remains largely unknown. We investigated the neurophysiological correlates of this reorganization by quantifying functional and effective brain network connectivity in elderly individuals (n = 11; mean age = 67.5 years), compared to young adults (n = 12; mean age = 23.7 years), while they performed visually-guided unimanual and bimanual handgrips inside the magnetoencephalography (MEG) scanner. Through a combination of principal component analysis and Granger causality, we observed age-related increases in functional and effective connectivity in whole-brain, task-related motor networks. Specifically, elderly individuals demonstrated (i) greater information flow from contralateral parietal and ipsilateral secondary motor regions to the left primary motor cortex during the unimanual task and (ii) decreased interhemispheric temporo-frontal communication during the bimanual task. Maintenance of motor performance and task accuracy in elderly was achieved by hyperactivation of the task-specific motor networks, reflecting a possible mechanism by which the aging brain recruits additional resources to counteract known myelo- and cytoarchitectural changes. Furthermore, resting-state sessions acquired before and after each motor task revealed that both older and younger adults maintain the capacity to adapt to task demands via network-wide increases in functional connectivity. Collectively, our study consolidates functional connectivity and directionality of information flow in systems-level cortical networks during aging and furthers our understanding of neuronal flexibility in motor processes.
Identifiants
pubmed: 30866155
doi: 10.1002/hbm.24578
pmc: PMC6548623
mid: NIHMS1017494
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3027-3040Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB026299
Pays : United States
Organisme : Fondation Brain Canada
ID : PSG15-3755
Pays : International
Organisme : Canada Foundation for Innovation
ID : 34277
Pays : International
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 436355-13
Pays : International
Organisme : Fonds de Recherche du Québec - Nature et Technologies
ID : 2016-PR191780
Pays : International
Organisme : Foundation for the National Institutes of Health
ID : 2R01EB009048-05
Pays : International
Organisme : NIBIB NIH HHS
ID : R01 EB009048
Pays : United States
Organisme : Canada Foundation for Innovation
ID : 34362
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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