Role of Protein Tyrosine Phosphatase Epsilon (PTP
Enzyme Activation
/ drug effects
Gene Expression Regulation
/ drug effects
HEK293 Cells
Humans
Interleukin-8
/ metabolism
Isoenzymes
/ metabolism
Leukotriene D4
/ pharmacology
Mitogen-Activated Protein Kinase 1
/ metabolism
Mitogen-Activated Protein Kinase 3
/ metabolism
Monocytes
/ drug effects
Protein Transport
/ drug effects
Receptor-Like Protein Tyrosine Phosphatases, Class 4
/ metabolism
Receptors, Leukotriene
/ metabolism
Journal
The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
28
11
2018
accepted:
06
03
2019
pubmed:
15
3
2019
medline:
21
12
2019
entrez:
15
3
2019
Statut:
ppublish
Résumé
Phosphorylation on tyrosine residues is recognized as an important mechanism for connecting extracellular stimuli to cellular events and defines a variety of physiologic responses downstream of G protein-coupled receptor (GPCR) activation. To date, few protein tyrosine phosphatases (PTPs) have been shown to associate with GPCRs, and little is known about their role in GPCR signaling. To discover potential cysteinyl-leukotriene receptor (CysLT
Identifiants
pubmed: 30867226
pii: jpet.118.255422
doi: 10.1124/jpet.118.255422
doi:
Substances chimiques
Interleukin-8
0
Isoenzymes
0
Receptors, Leukotriene
0
Leukotriene D4
73836-78-9
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Receptor-Like Protein Tyrosine Phosphatases, Class 4
EC 3.1.3.48
leukotriene D4 receptor
LRF7RW46ID
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
270-281Subventions
Organisme : CIHR
ID : MOP-142481
Pays : Canada
Informations de copyright
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics.