A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment.

Animals Anti-Bacterial Agents / therapeutic use Antitubercular Agents / pharmacology Delayed-Action Preparations Dose-Response Relationship, Drug Doxycycline / therapeutic use Drug Delivery Systems / economics Drug Liberation Humans Stomach / drug effects Swine Tuberculosis / drug therapy

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
13 03 2019
Historique:
received: 29 06 2018
accepted: 01 02 2019
entrez: 15 3 2019
pubmed: 15 3 2019
medline: 23 2 2020
Statut: ppublish

Résumé

Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.

Identifiants

DOI: 10.1126/scitranslmed.aau6267 PMID: 30867322 PMC: PMC7797620
pubmed: 30867322
pii: 11/483/eaau6267
doi: 10.1126/scitranslmed.aau6267
pmc: PMC7797620
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antitubercular Agents 0
Delayed-Action Preparations 0
Doxycycline N12000U13O

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Malvika Verma (M)

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0001-7043-5120

Karan Vishwanath (K)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-2910-9176

Feyisope Eweje (F)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Niclas Roxhed (N)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm 10044, Sweden.
ORCID: 0000-0002-7147-6730

Tyler Grant (T)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Macy Castaneda (M)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Christoph Steiger (C)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-5994-7819

Hormoz Mazdiyasni (H)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-1725-0877

Taylor Bensel (T)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Daniel Minahan (D)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-3065-055X

Vance Soares (V)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-4094-3316

John A F Salama (JAF)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Aaron Lopes (A)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Kaitlyn Hess (K)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-2837-0305

Cody Cleveland (C)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-2973-8530

Daniel J Fulop (DJ)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-1964-4861

Alison Hayward (A)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-9581-8563

Joy Collins (J)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-9232-4517

Siddartha M Tamang (SM)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Tiffany Hua (T)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Chinonyelum Ikeanyi (C)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Gal Zeidman (G)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-9888-489X

Elizabeth Mule (E)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-0081-3971

Sooraj Boominathan (S)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Ellena Popova (E)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0002-9624-0628

Jonathan B Miller (JB)

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-4610-0210

Andrew M Bellinger (AM)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cardiovascular Division, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

David Collins (D)

Management Sciences for Health, Medford, MA 02155, USA.
Boston University School of Public Health, Boston, MA 02118, USA.
ORCID: 0000-0002-4327-5907

Dalia Leibowitz (D)

Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Shelly Batra (S)

Operation ASHA, New Delhi 110076, India.

Sandeep Ahuja (S)

Operation ASHA, New Delhi 110076, India.

Manju Bajiya (M)

Operation ASHA, New Delhi 110076, India.

Sonali Batra (S)

Operation ASHA, New Delhi 110076, India.
ORCID: 0000-0003-2921-9295

Rohit Sarin (R)

National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.

Upasna Agarwal (U)

National Institute of Tuberculosis and Respiratory Diseases, New Delhi 110030, India.

Sunil D Khaparde (SD)

Former Deputy Director General and Head of Central TB Division, Government of India, New Delhi 110011, India.

Neeraj K Gupta (NK)

Department of Respiratory Medicine, Safdarjung Hospital, New Delhi 110029, India.

Deepak Gupta (D)

Division of Pulmonary and Critical Care Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.

Anuj K Bhatnagar (AK)

Rajan Babu Institute for Pulmonary Medicine and Tuberculosis, New Delhi 110009, India.
ORCID: 0000-0002-4152-2660

Kamal K Chopra (KK)

New Delhi Tuberculosis Centre, New Delhi 110002, India.

Nandini Sharma (N)

Department of Community Medicine, Maulana Azad Medical College, New Delhi 110002, India.

Ashwani Khanna (A)

Lok Nayak Hospital Chest Clinic, New Delhi 110002, India.

Jayeeta Chowdhury (J)

Tata Trusts, Mumbai 400001, India.

Robert Stoner (R)

Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
MIT Energy Initiative, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Alexander H Slocum (AH)

Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Michael J Cima (MJ)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-2379-6139

Jennifer Furin (J)

Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-0825-7199

Robert Langer (R)

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. rlanger@mit.edu ctraverso@bwh.harvard.edu cgt20@mit.edu.
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0003-4255-0492

Giovanni Traverso (G)

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. rlanger@mit.edu ctraverso@bwh.harvard.edu cgt20@mit.edu.
Tata Center for Technology and Design, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID: 0000-0001-7851-4077

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A gastric resident drug delivery system for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › A gastric resident drug delivery system for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › A gastric resident drug delivery system for...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Préparations à action retardée › A gastric resident drug delivery system for...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › A gastric resident drug delivery system for...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtacènes › Tétracyclines › Doxycycline › A gastric resident drug delivery system for...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › A gastric resident drug delivery system for...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › A gastric resident drug delivery system for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A gastric resident drug delivery system for...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif supérieur › Estomac › A gastric resident drug delivery system for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › A gastric resident drug delivery system for...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › A gastric resident drug delivery system for...