Sirolimus and mTOR Inhibitors: A Review of Side Effects and Specific Management in Solid Organ Transplantation.

Humans Immunosuppressive Agents / adverse effects Organ Transplantation Sirolimus / adverse effects TOR Serine-Threonine Kinases / antagonists & inhibitors

Journal

Drug safety
ISSN: 1179-1942
Titre abrégé: Drug Saf
Pays: New Zealand
ID NLM: 9002928

Informations de publication

Date de publication:
07 2019
Historique:
pubmed: 15 3 2019
medline: 12 2 2020
entrez: 15 3 2019
Statut: ppublish

Résumé

Inhibitors of mechanistic target of rapamycin (mTOR inhibitors) are used as antiproliferative immunosuppressive drugs and have many clinical applications in various drug combinations. Experience in transplantation studies has been gained regarding the side effect profile of these drugs and the potential benefits and limitations compared with other immunosuppressive agents. This article reviews the adverse effects of mTOR inhibitors in solid organ transplantation, with special attention given to mechanisms hypothesized to cause adverse events and their management strategies.

Identifiants

DOI: 10.1007/s40264-019-00810-9 PMID: 30868436
pubmed: 30868436
doi: 10.1007/s40264-019-00810-9
pii: 10.1007/s40264-019-00810-9
doi:

Substances chimiques

Immunosuppressive Agents 0
MTOR protein, human EC 2.7.1.1
TOR Serine-Threonine Kinases EC 2.7.11.1
Sirolimus W36ZG6FT64

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

813-825

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Auteurs

Lee S Nguyen (LS)

Clinical Pharmacology & Center of Clinical Investigation Paris-Est, Sorbonne Université, AP-HP, INSERM, Paris, France. nguyen.lee@icloud.com.
Service de chirurgie cardiaque, Institut de Cardiologie, AP-HP, Pitié-Salpétrière University Hospital, ICAN, INSERM, Sorbonne Université, 47-53 Boulevard de l'Hopital, 75013, Paris, France. nguyen.lee@icloud.com.
ORCID: 0000-0002-6014-6269

Mathieu Vautier (M)

Department of Internal Medicine, Pitié-Salpétrière University Hospital, AP-HP, Sorbonne Université, Paris, France.

Yves Allenbach (Y)

Department of Internal Medicine, Pitié-Salpétrière University Hospital, AP-HP, Sorbonne Université, Paris, France.

Noel Zahr (N)

Clinical Pharmacology & Center of Clinical Investigation Paris-Est, Sorbonne Université, AP-HP, INSERM, Paris, France.

Olivier Benveniste (O)

Department of Internal Medicine, Pitié-Salpétrière University Hospital, AP-HP, Sorbonne Université, Paris, France.

Christian Funck-Brentano (C)

Clinical Pharmacology & Center of Clinical Investigation Paris-Est, Sorbonne Université, AP-HP, INSERM, Paris, France.

Joe-Elie Salem (JE)

Clinical Pharmacology & Center of Clinical Investigation Paris-Est, Sorbonne Université, AP-HP, INSERM, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sirolimus and mTOR Inhibitors: A Review of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Sirolimus and mTOR Inhibitors: A Review of...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation d'organe › Sirolimus and mTOR Inhibitors: A Review of...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Sirolimus › Sirolimus and mTOR Inhibitors: A Review of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Sirolimus and mTOR Inhibitors: A Review of...