The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study.
breast milk
control formula
early life nutrition
exclusive breastfeeding
fatty acid desaturases
fatty acids
infant formula
intervention formula
omega 3
omega 6
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
12 Mar 2019
12 Mar 2019
Historique:
received:
13
12
2018
accepted:
05
03
2019
entrez:
16
3
2019
pubmed:
16
3
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Polymorphisms in the fatty acid desaturase (FADS) genes influence the arachidonic (AA) and docosahexaenoic (DHA) acid concentrations (crucial in early life). Infants with specific genotypes may require different amounts of these fatty acids (FAs) to maintain an adequate status. The aim of this study was to determine the effect of an infant formula supplemented with AA and DHA on FAs of infants with different FADS genotypes. In total, 176 infants from the COGNIS study were randomly allocated to the Standard Formula (SF; n = 61) or the Experimental Formula (EF; n = 70) group, the latter supplemented with AA and DHA. Breastfed infants were added as a reference group (BF; n = 45). FAs and FADS polymorphisms were analyzed from cheek cells collected at 3 months of age. FADS minor allele carriership in formula fed infants, especially those supplemented, was associated with a declined desaturase activity and lower AA and DHA levels. Breastfed infants were not affected, possibly to the high content of AA and DHA in breast milk. The supplementation increased AA and DHA levels, but mostly in major allele carriers. In conclusion, infant FADS genotype could contribute to narrow the gap of AA and DHA concentrations between breastfed and formula fed infants.
Identifiants
pubmed: 30871048
pii: nu11030602
doi: 10.3390/nu11030602
pmc: PMC6470942
pii:
doi:
Substances chimiques
Fatty Acids
0
Docosahexaenoic Acids
25167-62-8
Arachidonic Acid
27YG812J1I
Fatty Acid Desaturases
EC 1.14.19.-
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ORDESA Laboratories, S.L., Spanish Ministry of Econmy, Industry and Competitiveness, NEOBEFOOD Project (2010-2013) and SMARTFOODS Project (2014-2018) - CIEN Strategy (Ministry of Innovation and Science-CDTI), and partially funded by EU Project DynaHEALTH
ID : University of Granada General Foundation (ref. nº 3349 and nº 4003, respectively) and between Ordesa Laboratories and the Bosch Gimpera Foundation/University of Barcelona (ref. nº 306811 and 308516). EU Project DynaHEALTH (HORIZON 2020-GA No.633595).
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